| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ak9 | Sigirr | ENSRNOP00000054014 | ENSRNOP00000051758 | Adenylate kinase 9. | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). | 0.630 |
| Fbxl19 | Sigirr | ENSRNOP00000075629 | ENSRNOP00000051758 | F-box and leucine-rich repeat protein 19. | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). | 0.508 |
| Irak1 | Irak3 | ENSRNOP00000070832 | ENSRNOP00000005686 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Interleukin-1 receptor-associated kinase 3 (Predicted). | 0.993 |
| Irak1 | Irak4 | ENSRNOP00000070832 | ENSRNOP00000007932 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Interleukin-1 receptor-associated kinase 4. | 0.999 |
| Irak1 | Myd88 | ENSRNOP00000070832 | ENSRNOP00000018341 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.999 |
| Irak1 | Sigirr | ENSRNOP00000070832 | ENSRNOP00000051758 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). | 0.638 |
| Irak1 | Tlr4 | ENSRNOP00000070832 | ENSRNOP00000014020 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.834 |
| Irak1 | Tlr5 | ENSRNOP00000070832 | ENSRNOP00000004821 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Toll-like receptor 5; Belongs to the Toll-like receptor family. | 0.760 |
| Irak1 | Tollip | ENSRNOP00000070832 | ENSRNOP00000049498 | Interleukin-1 receptor-associated kinase 1 (Predicted). | Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). | 0.985 |
| Irak1 | Traf6 | ENSRNOP00000070832 | ENSRNOP00000006148 | Interleukin-1 receptor-associated kinase 1 (Predicted). | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.999 |
| Irak3 | Irak1 | ENSRNOP00000005686 | ENSRNOP00000070832 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Interleukin-1 receptor-associated kinase 1 (Predicted). | 0.993 |
| Irak3 | Irak4 | ENSRNOP00000005686 | ENSRNOP00000007932 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Interleukin-1 receptor-associated kinase 4. | 0.984 |
| Irak3 | Myd88 | ENSRNOP00000005686 | ENSRNOP00000018341 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.807 |
| Irak3 | Sigirr | ENSRNOP00000005686 | ENSRNOP00000051758 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). | 0.519 |
| Irak3 | Tlr4 | ENSRNOP00000005686 | ENSRNOP00000014020 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] | 0.593 |
| Irak3 | Tlr5 | ENSRNOP00000005686 | ENSRNOP00000004821 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Toll-like receptor 5; Belongs to the Toll-like receptor family. | 0.422 |
| Irak3 | Tollip | ENSRNOP00000005686 | ENSRNOP00000049498 | Interleukin-1 receptor-associated kinase 3 (Predicted). | Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). | 0.700 |
| Irak3 | Traf6 | ENSRNOP00000005686 | ENSRNOP00000006148 | Interleukin-1 receptor-associated kinase 3 (Predicted). | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.991 |
| Irak4 | Irak1 | ENSRNOP00000007932 | ENSRNOP00000070832 | Interleukin-1 receptor-associated kinase 4. | Interleukin-1 receptor-associated kinase 1 (Predicted). | 0.999 |
| Irak4 | Irak3 | ENSRNOP00000007932 | ENSRNOP00000005686 | Interleukin-1 receptor-associated kinase 4. | Interleukin-1 receptor-associated kinase 3 (Predicted). | 0.984 |
