STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mrc2C-type mannose receptor 2; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix coope [...] (1514 aa)    
Predicted Functional Partners:
Mrc1
Mannose receptor, C type 1.
     
0.903
Pla2r1
Mannose receptor, C type 2 (Predicted).
     
 
0.900
Plau
Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
    
 
 0.576
Fcgr1a
Fc fragment of IgG receptor Ia.
     
 0.541
Rabepk
Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
    
 
 0.518
Plaur
Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
      
 0.517
Zfp958-2
Uncharacterized protein.
    
 
 0.515
Zfp182
Zinc finger protein 182.
    
 
 0.508
Col6a2
Procollagen, type VI, alpha 2, isoform CRA_a.
   
   0.500
Cd207
CD207 molecule.
     
 
0.499
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: high (84%) [HD]