Tyms protein (Rattus norvegicus) - STRING interaction network

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Tyms

Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. (307 aa)

Predicted Functional Partners:

Dhfr

0.999

Tk1

0.991

Mthfr

0.981

Shmt1

0.979

Shmt2

0.974

Dtymk

0.967

Rrm1

0.967

Dctd

0.966

Mthfd2

0.964

Fpgs

0.964

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dctd	Dhfr	ENSRNOP00000017670	ENSRNOP00000018259	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	0.602
Dctd	Dtymk	ENSRNOP00000017670	ENSRNOP00000025644	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	Deoxythymidylate kinase (Predicted), isoform CRA_b.	0.930
Dctd	Tk1	ENSRNOP00000017670	ENSRNOP00000067459	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	Thymidine kinase, cytosolic; Belongs to the thymidine kinase family.	0.943
Dctd	Tyms	ENSRNOP00000017670	ENSRNOP00000053086	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.	0.966
Dhfr	Dctd	ENSRNOP00000018259	ENSRNOP00000017670	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	0.602
Dhfr	Dtymk	ENSRNOP00000018259	ENSRNOP00000025644	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Deoxythymidylate kinase (Predicted), isoform CRA_b.	0.798
Dhfr	Fpgs	ENSRNOP00000018259	ENSRNOP00000064076	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Folylpolyglutamate synthase.	0.971
Dhfr	Mthfd2	ENSRNOP00000018259	ENSRNOP00000014603	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	RCG56426.	0.805
Dhfr	Mthfr	ENSRNOP00000018259	ENSRNOP00000011384	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.936
Dhfr	Rrm1	ENSRNOP00000018259	ENSRNOP00000064166	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.552
Dhfr	Shmt1	ENSRNOP00000018259	ENSRNOP00000007092	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.982
Dhfr	Shmt2	ENSRNOP00000018259	ENSRNOP00000011082	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.974
Dhfr	Tk1	ENSRNOP00000018259	ENSRNOP00000067459	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Thymidine kinase, cytosolic; Belongs to the thymidine kinase family.	0.871
Dhfr	Tyms	ENSRNOP00000018259	ENSRNOP00000053086	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.	0.999
Dtymk	Dctd	ENSRNOP00000025644	ENSRNOP00000017670	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.	0.930
Dtymk	Dhfr	ENSRNOP00000025644	ENSRNOP00000018259	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).	0.798
Dtymk	Rrm1	ENSRNOP00000025644	ENSRNOP00000064166	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.947
Dtymk	Shmt1	ENSRNOP00000025644	ENSRNOP00000007092	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.412
Dtymk	Shmt2	ENSRNOP00000025644	ENSRNOP00000011082	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.411
Dtymk	Tk1	ENSRNOP00000025644	ENSRNOP00000067459	Deoxythymidylate kinase (Predicted), isoform CRA_b.	Thymidine kinase, cytosolic; Belongs to the thymidine kinase family.	0.959

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