node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bace1 | Plscr1 | ENSRNOP00000022796 | ENSRNOP00000053569 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity); Belongs to the peptidase A1 family. | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.465 |
Ddit4 | Plscr1 | ENSRNOP00000073198 | ENSRNOP00000053569 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell typ [...] | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.555 |
Helz2 | Herc6 | ENSRNOP00000017787 | ENSRNOP00000055422 | Helicase with zinc finger 2. | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | 0.416 |
Helz2 | Isg15 | ENSRNOP00000017787 | ENSRNOP00000035405 | Helicase with zinc finger 2. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.685 |
Helz2 | Plscr1 | ENSRNOP00000017787 | ENSRNOP00000053569 | Helicase with zinc finger 2. | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.482 |
Helz2 | Rsad2 | ENSRNOP00000017787 | ENSRNOP00000010092 | Helicase with zinc finger 2. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.575 |
Helz2 | Stat2 | ENSRNOP00000017787 | ENSRNOP00000075125 | Helicase with zinc finger 2. | Signal transducer and activator of transcription. | 0.479 |
Herc6 | Helz2 | ENSRNOP00000055422 | ENSRNOP00000017787 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Helicase with zinc finger 2. | 0.416 |
Herc6 | Ifi44 | ENSRNOP00000055422 | ENSRNOP00000071211 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Interferon-induced protein 44, isoform CRA_a. | 0.843 |
Herc6 | Isg15 | ENSRNOP00000055422 | ENSRNOP00000035405 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.929 |
Herc6 | Plscr1 | ENSRNOP00000055422 | ENSRNOP00000053569 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.516 |
Herc6 | Rsad2 | ENSRNOP00000055422 | ENSRNOP00000010092 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.830 |
Herc6 | Stat1 | ENSRNOP00000055422 | ENSRNOP00000070183 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Signal transducer and activator of transcription. | 0.515 |
Herc6 | Stat2 | ENSRNOP00000055422 | ENSRNOP00000075125 | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | Signal transducer and activator of transcription. | 0.423 |
Ifi44 | Herc6 | ENSRNOP00000071211 | ENSRNOP00000055422 | Interferon-induced protein 44, isoform CRA_a. | HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6. | 0.843 |
Ifi44 | Isg15 | ENSRNOP00000071211 | ENSRNOP00000035405 | Interferon-induced protein 44, isoform CRA_a. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.944 |
Ifi44 | Plscr1 | ENSRNOP00000071211 | ENSRNOP00000053569 | Interferon-induced protein 44, isoform CRA_a. | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. | 0.478 |
Ifi44 | Rsad2 | ENSRNOP00000071211 | ENSRNOP00000010092 | Interferon-induced protein 44, isoform CRA_a. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.970 |
Ifi44 | Stat1 | ENSRNOP00000071211 | ENSRNOP00000070183 | Interferon-induced protein 44, isoform CRA_a. | Signal transducer and activator of transcription. | 0.864 |
Ifi44 | Stat2 | ENSRNOP00000071211 | ENSRNOP00000075125 | Interferon-induced protein 44, isoform CRA_a. | Signal transducer and activator of transcription. | 0.598 |