Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Adam6aA disintegrin and metallopeptidase domain 6A. (751 aa)    
Predicted Functional Partners:
Tryx5
Trypsin X5; Belongs to the peptidase S1 family.
   
  
 0.622
Zc2hc1b
Zinc finger, C2HC-type-containing 1B.
   
  
 0.603
Adam3a
ADAM metallopeptidase domain 3A.
  
 
0.505
Adam5
Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity).
  
 
0.497
Clgn
Calmegin.
   
 
 0.479
Pdilt
Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.
   
 
 0.468
Prss55
Serine protease 55; Belongs to the peptidase S1 family.
      
 0.459
Tmprss12
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
  
 0.454
Prss37
Similar to RIKEN cDNA 1700016G05 (Predicted).
   
  
 0.432
LOC100360238
Disintegrin and metalloproteinase domain-containing protein 1; May be involved in sperm-egg fusion.
  
 
0.425
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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