node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dis3l2 | Dusp11 | ENSRNOP00000073968 | ENSRNOP00000054285 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | Dual specificity phosphatase 11. | 0.585 |
Dis3l2 | Xrn1 | ENSRNOP00000073968 | ENSRNOP00000014481 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | 5'-3' exoribonuclease 1. | 0.736 |
Dusp11 | Dis3l2 | ENSRNOP00000054285 | ENSRNOP00000073968 | Dual specificity phosphatase 11. | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | 0.585 |
Dusp11 | Dusp21 | ENSRNOP00000054285 | ENSRNOP00000000173 | Dual specificity phosphatase 11. | Dual-specificity phosphatase 21; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.612 |
Dusp11 | Dxo | ENSRNOP00000054285 | ENSRNOP00000000483 | Dual specificity phosphatase 11. | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 0.769 |
Dusp11 | LOC108348149 | ENSRNOP00000054285 | ENSRNOP00000002381 | Dual specificity phosphatase 11. | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] | 0.619 |
Dusp11 | Ncbp2 | ENSRNOP00000054285 | ENSRNOP00000066677 | Dual specificity phosphatase 11. | Nuclear cap binding protein subunit 2. | 0.669 |
Dusp11 | Ncor1 | ENSRNOP00000054285 | ENSRNOP00000072175 | Dual specificity phosphatase 11. | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB [...] | 0.579 |
Dusp11 | Ncor2 | ENSRNOP00000054285 | ENSRNOP00000001334 | Dual specificity phosphatase 11. | Nuclear receptor co-repressor 2 (Predicted), isoform CRA_a. | 0.579 |
Dusp11 | Pigb | ENSRNOP00000054285 | ENSRNOP00000073341 | Dual specificity phosphatase 11. | Mannosyltransferase. | 0.548 |
Dusp11 | Supt5h | ENSRNOP00000054285 | ENSRNOP00000049521 | Dual specificity phosphatase 11. | Transcription elongation factor SPT5. | 0.642 |
Dusp11 | Xrn1 | ENSRNOP00000054285 | ENSRNOP00000014481 | Dual specificity phosphatase 11. | 5'-3' exoribonuclease 1. | 0.664 |
Dusp21 | Dusp11 | ENSRNOP00000000173 | ENSRNOP00000054285 | Dual-specificity phosphatase 21; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Dual specificity phosphatase 11. | 0.612 |
Dxo | Dusp11 | ENSRNOP00000000483 | ENSRNOP00000054285 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | Dual specificity phosphatase 11. | 0.769 |
Dxo | Xrn1 | ENSRNOP00000000483 | ENSRNOP00000014481 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 5'-3' exoribonuclease 1. | 0.717 |
LOC108348149 | Dusp11 | ENSRNOP00000002381 | ENSRNOP00000054285 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] | Dual specificity phosphatase 11. | 0.619 |
LOC108348149 | Ncbp2 | ENSRNOP00000002381 | ENSRNOP00000066677 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] | Nuclear cap binding protein subunit 2. | 0.900 |
LOC108348149 | Supt5h | ENSRNOP00000002381 | ENSRNOP00000049521 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] | Transcription elongation factor SPT5. | 0.606 |
Ncbp2 | Dusp11 | ENSRNOP00000066677 | ENSRNOP00000054285 | Nuclear cap binding protein subunit 2. | Dual specificity phosphatase 11. | 0.669 |
Ncbp2 | LOC108348149 | ENSRNOP00000066677 | ENSRNOP00000002381 | Nuclear cap binding protein subunit 2. | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] | 0.900 |