node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcs1l | Lyrm7 | ENSRNOP00000022632 | ENSRNOP00000065804 | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.680 |
Bcs1l | Timm22 | ENSRNOP00000022632 | ENSRNOP00000010779 | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. | Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Belongs to the Tim17/Tim22/Tim23 family. | 0.524 |
Bcs1l | Ttc19 | ENSRNOP00000022632 | ENSRNOP00000054591 | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity; Belongs to the TTC19 family. | 0.691 |
Bcs1l | Uqcc3 | ENSRNOP00000022632 | ENSRNOP00000064397 | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. | Ubiquinol-cytochrome-c reductase complex assembly factor 3; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology; Belongs to the UQCC3 family. | 0.525 |
Blmh | Dnajb12 | ENSRNOP00000005125 | ENSRNOP00000049600 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | DnaJ heat shock protein family (Hsp40) member B12. | 0.665 |
Blmh | LOC102550385 | ENSRNOP00000005125 | ENSRNOP00000065815 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | LYR motif-containing 4; Belongs to the complex I LYR family. | 0.606 |
Blmh | Ttc19 | ENSRNOP00000005125 | ENSRNOP00000054591 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity; Belongs to the TTC19 family. | 0.673 |
Blmh | Usp37 | ENSRNOP00000005125 | ENSRNOP00000033308 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.596 |
Blmh | Wdr73 | ENSRNOP00000005125 | ENSRNOP00000029102 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | Neuromedin B (Predicted), isoform CRA_d. | 0.645 |
Dnajb12 | Blmh | ENSRNOP00000049600 | ENSRNOP00000005125 | DnaJ heat shock protein family (Hsp40) member B12. | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | 0.665 |
Dnajb12 | LOC102550385 | ENSRNOP00000049600 | ENSRNOP00000065815 | DnaJ heat shock protein family (Hsp40) member B12. | LYR motif-containing 4; Belongs to the complex I LYR family. | 0.634 |
Dnajb12 | Ttc19 | ENSRNOP00000049600 | ENSRNOP00000054591 | DnaJ heat shock protein family (Hsp40) member B12. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity; Belongs to the TTC19 family. | 0.732 |
Dnajb12 | Usp37 | ENSRNOP00000049600 | ENSRNOP00000033308 | DnaJ heat shock protein family (Hsp40) member B12. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.617 |
Dnajb12 | Wdr73 | ENSRNOP00000049600 | ENSRNOP00000029102 | DnaJ heat shock protein family (Hsp40) member B12. | Neuromedin B (Predicted), isoform CRA_d. | 0.663 |
LOC102550385 | Blmh | ENSRNOP00000065815 | ENSRNOP00000005125 | LYR motif-containing 4; Belongs to the complex I LYR family. | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics; Belongs to the peptidase C1 family. | 0.606 |
LOC102550385 | Dnajb12 | ENSRNOP00000065815 | ENSRNOP00000049600 | LYR motif-containing 4; Belongs to the complex I LYR family. | DnaJ heat shock protein family (Hsp40) member B12. | 0.634 |
LOC102550385 | Lyrm7 | ENSRNOP00000065815 | ENSRNOP00000065804 | LYR motif-containing 4; Belongs to the complex I LYR family. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.668 |
LOC102550385 | Ttc19 | ENSRNOP00000065815 | ENSRNOP00000054591 | LYR motif-containing 4; Belongs to the complex I LYR family. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity; Belongs to the TTC19 family. | 0.701 |
LOC102550385 | Usp37 | ENSRNOP00000065815 | ENSRNOP00000033308 | LYR motif-containing 4; Belongs to the complex I LYR family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.651 |
LOC102550385 | Wdr73 | ENSRNOP00000065815 | ENSRNOP00000029102 | LYR motif-containing 4; Belongs to the complex I LYR family. | Neuromedin B (Predicted), isoform CRA_d. | 0.665 |