STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defb4Beta-defensin 4; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells. (63 aa)    
Predicted Functional Partners:
Defb1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.
   
 
 0.992
Defb14
Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.956
Defb24
Beta-defensin 24.
     
 0.806
Defb36
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.721
Defb2
Beta-defensin 2.
      
 0.679
Defb18
Beta-defensin 18; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.628
Defb30
Beta-defensin 30; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.590
Ccr6
Chemokine (C-C motif) receptor 6; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.588
Defb27
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.574
Defb37
Beta-defensin 37.
      
 0.571
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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