node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acd | Blm | ENSRNOP00000056334 | ENSRNOP00000015065 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Bloom syndrome, RecQ helicase-like | 0.912 |
Acd | Fen1 | ENSRNOP00000056334 | ENSRNOP00000027842 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] | 0.906 |
Acd | LOC100911727 | ENSRNOP00000056334 | ENSRNOP00000061228 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | DNA ligase 1-like | 0.902 |
Acd | Pot1 | ENSRNOP00000056334 | ENSRNOP00000057203 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Similar to POT1-like telomere end-binding protein; Protection of telomeres 1 | 0.992 |
Acd | Pot1b | ENSRNOP00000056334 | ENSRNOP00000064381 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Protection of telomeres 1B | 0.992 |
Acd | RGD1564788 | ENSRNOP00000056334 | ENSRNOP00000055596 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Werner syndrome atp-dependent helicase; Werner syndrome, RecQ helicase-like | 0.922 |
Acd | Terf1 | ENSRNOP00000056334 | ENSRNOP00000043160 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Telomeric repeat binding factor (NIMA-interacting) 1 | 0.995 |
Acd | Terf2 | ENSRNOP00000056334 | ENSRNOP00000027695 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Telomeric repeat binding factor 2 | 0.971 |
Acd | Terf2ip | ENSRNOP00000056334 | ENSRNOP00000014660 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HD [...] | 0.996 |
Acd | Tinf2 | ENSRNOP00000056334 | ENSRNOP00000027362 | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | TERF1 (TRF1)-interacting nuclear factor 2 | 0.998 |
Blm | Acd | ENSRNOP00000015065 | ENSRNOP00000056334 | Bloom syndrome, RecQ helicase-like | Acd, shelterin complex subunit and telomerase recruitment factor; Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibit [...] | 0.912 |
Blm | Fen1 | ENSRNOP00000015065 | ENSRNOP00000027842 | Bloom syndrome, RecQ helicase-like | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] | 0.956 |
Blm | LOC100911727 | ENSRNOP00000015065 | ENSRNOP00000061228 | Bloom syndrome, RecQ helicase-like | DNA ligase 1-like | 0.524 |
Blm | Pot1 | ENSRNOP00000015065 | ENSRNOP00000057203 | Bloom syndrome, RecQ helicase-like | Similar to POT1-like telomere end-binding protein; Protection of telomeres 1 | 0.505 |
Blm | Pot1b | ENSRNOP00000015065 | ENSRNOP00000064381 | Bloom syndrome, RecQ helicase-like | Protection of telomeres 1B | 0.505 |
Blm | RGD1564788 | ENSRNOP00000015065 | ENSRNOP00000055596 | Bloom syndrome, RecQ helicase-like | Werner syndrome atp-dependent helicase; Werner syndrome, RecQ helicase-like | 0.801 |
Blm | Terf1 | ENSRNOP00000015065 | ENSRNOP00000043160 | Bloom syndrome, RecQ helicase-like | Telomeric repeat binding factor (NIMA-interacting) 1 | 0.935 |
Blm | Terf2 | ENSRNOP00000015065 | ENSRNOP00000027695 | Bloom syndrome, RecQ helicase-like | Telomeric repeat binding factor 2 | 0.983 |
Blm | Terf2ip | ENSRNOP00000015065 | ENSRNOP00000014660 | Bloom syndrome, RecQ helicase-like | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HD [...] | 0.916 |
Blm | Tinf2 | ENSRNOP00000015065 | ENSRNOP00000027362 | Bloom syndrome, RecQ helicase-like | TERF1 (TRF1)-interacting nuclear factor 2 | 0.924 |