LOC100911068 protein (Rattus norvegicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	LOC100911068	ENSRNOP00000064048	ENSRNOP00000057050	Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space.	Roundabout homolog 4-like.	0.658
Dipk2b	LOC100911068	ENSRNOP00000005659	ENSRNOP00000057050	Divergent protein kinase domain 2B.	Roundabout homolog 4-like.	0.909
LOC100911068	Cldn5	ENSRNOP00000057050	ENSRNOP00000064048	Roundabout homolog 4-like.	Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space.	0.658
LOC100911068	Dipk2b	ENSRNOP00000057050	ENSRNOP00000005659	Roundabout homolog 4-like.	Divergent protein kinase domain 2B.	0.909
LOC100911068	Lrtm2	ENSRNOP00000057050	ENSRNOP00000010238	Roundabout homolog 4-like.	Leucine-rich repeats and transmembrane domains 2.	0.632
LOC100911068	Nck2	ENSRNOP00000057050	ENSRNOP00000023029	Roundabout homolog 4-like.	Cytoplasmic protein.	0.691
LOC100911068	Pak6	ENSRNOP00000057050	ENSRNOP00000075254	Roundabout homolog 4-like.	Non-specific serine/threonine protein kinase.	0.653
LOC100911068	Robo1	ENSRNOP00000057050	ENSRNOP00000069709	Roundabout homolog 4-like.	Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migratio [...]	0.662
LOC100911068	Robo3	ENSRNOP00000057050	ENSRNOP00000060623	Roundabout homolog 4-like.	Roundabout homolog 3 (Drosophila) (Predicted).	0.732
LOC100911068	Slit1	ENSRNOP00000057050	ENSRNOP00000035315	Roundabout homolog 4-like.	Slit homolog 1 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity).	0.959
LOC100911068	Slit2	ENSRNOP00000057050	ENSRNOP00000005477	Roundabout homolog 4-like.	Slit homolog 2 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they [...]	0.983
LOC100911068	Slit3	ENSRNOP00000057050	ENSRNOP00000009714	Roundabout homolog 4-like.	Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.	0.950
Lrtm2	LOC100911068	ENSRNOP00000010238	ENSRNOP00000057050	Leucine-rich repeats and transmembrane domains 2.	Roundabout homolog 4-like.	0.632
Lrtm2	Robo1	ENSRNOP00000010238	ENSRNOP00000069709	Leucine-rich repeats and transmembrane domains 2.	Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migratio [...]	0.478
Nck2	LOC100911068	ENSRNOP00000023029	ENSRNOP00000057050	Cytoplasmic protein.	Roundabout homolog 4-like.	0.691
Nck2	Pak6	ENSRNOP00000023029	ENSRNOP00000075254	Cytoplasmic protein.	Non-specific serine/threonine protein kinase.	0.955
Nck2	Robo1	ENSRNOP00000023029	ENSRNOP00000069709	Cytoplasmic protein.	Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migratio [...]	0.909
Pak6	LOC100911068	ENSRNOP00000075254	ENSRNOP00000057050	Non-specific serine/threonine protein kinase.	Roundabout homolog 4-like.	0.653
Pak6	Nck2	ENSRNOP00000075254	ENSRNOP00000023029	Non-specific serine/threonine protein kinase.	Cytoplasmic protein.	0.955
Pak6	Robo1	ENSRNOP00000075254	ENSRNOP00000069709	Non-specific serine/threonine protein kinase.	Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migratio [...]	0.898

page 1 of 3

Server load: low (22%) [HD]

Share

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About