node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hspb1 | Mapk11 | ENSRNOP00000032902 | ENSRNOP00000009325 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | Mitogen-activated protein kinase. | 0.784 |
Hspb1 | Mapk12 | ENSRNOP00000032902 | ENSRNOP00000046455 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.521 |
Hspb1 | Mapk13 | ENSRNOP00000032902 | ENSRNOP00000000621 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.508 |
Hspb1 | Mapk14 | ENSRNOP00000032902 | ENSRNOP00000000617 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.833 |
Hspb1 | Mapkapk2 | ENSRNOP00000032902 | ENSRNOP00000057786 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | MAPK-activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.994 |
Hspb1 | Mapkapk3 | ENSRNOP00000032902 | ENSRNOP00000020065 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to [...] | 0.969 |
Lsp1 | Mapkapk2 | ENSRNOP00000051747 | ENSRNOP00000057786 | Lymphocyte specific 1, isoform CRA_a. | MAPK-activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.930 |
Map2k6 | Mapk11 | ENSRNOP00000006217 | ENSRNOP00000009325 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.969 |
Map2k6 | Mapk12 | ENSRNOP00000006217 | ENSRNOP00000046455 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.962 |
Map2k6 | Mapk13 | ENSRNOP00000006217 | ENSRNOP00000000621 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.962 |
Map2k6 | Mapk14 | ENSRNOP00000006217 | ENSRNOP00000000617 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.979 |
Map2k6 | Mapkapk2 | ENSRNOP00000006217 | ENSRNOP00000057786 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | MAPK-activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.935 |
Map2k6 | Mapkapk3 | ENSRNOP00000006217 | ENSRNOP00000020065 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to [...] | 0.605 |
Mapk11 | Hspb1 | ENSRNOP00000009325 | ENSRNOP00000032902 | Mitogen-activated protein kinase. | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. | 0.784 |
Mapk11 | Map2k6 | ENSRNOP00000009325 | ENSRNOP00000006217 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | 0.969 |
Mapk11 | Mapk12 | ENSRNOP00000009325 | ENSRNOP00000046455 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.655 |
Mapk11 | Mapk13 | ENSRNOP00000009325 | ENSRNOP00000000621 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.624 |
Mapk11 | Mapk14 | ENSRNOP00000009325 | ENSRNOP00000000617 | Mitogen-activated protein kinase. | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.571 |
Mapk11 | Mapkapk2 | ENSRNOP00000009325 | ENSRNOP00000057786 | Mitogen-activated protein kinase. | MAPK-activated protein kinase 2; Belongs to the protein kinase superfamily. | 0.987 |
Mapk11 | Mapkapk3 | ENSRNOP00000009325 | ENSRNOP00000020065 | Mitogen-activated protein kinase. | MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to [...] | 0.965 |