STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tgm3Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 o [...] (693 aa)    
Predicted Functional Partners:
Cnfn
Similar to cornifelin (Predicted), isoform CRA_a.
   
  
 0.745
Casp14
Caspase 14; Belongs to the peptidase C14A family.
   
 
 0.656
Crnn
Cornulin.
   
 
 0.633
Krt80
Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family.
      
 0.632
Sprr3
Small proline-rich protein 3 (Predicted).
   
  
 0.605
Tchh
Trichohyalin.
   
 
 0.590
Eda2r
Ectodysplasin A2 isoform receptor (Predicted), isoform CRA_a.
      
 0.559
Hrnr
EF-hand domain-containing protein.
   
 
 0.558
Serpinb12
Serpin family B member 12; Belongs to the serpin family.
   
 
 0.553
Dsg4
Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
    
 
 0.531
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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