STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Colec12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-oros [...] (742 aa)    
Predicted Functional Partners:
Pla2g2e
Phospholipase A2, group IIE (Predicted), isoform CRA_a.
      
 0.561
Col8a1
Collagen type VIII alpha 1 chain.
  
 
 0.555
Klra5-2
Killer cell lectin-like receptor 5.
      
 0.504
Klra5
Killer cell lectin-like receptor, subfamily A, member 5.
   
  
 0.501
Col23a1
Collagen alpha-1(XXIII) chain.
  
 
 
 0.487
LOC103693323
Collagen alpha-1(XXIII) chain.
  
 
 
 0.476
Cert1
Procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein (Predicted), isoform CRA_a.
      
 0.440
Colgalt2
Collagen beta(1-O)galactosyltransferase 2.
    
 
 0.421
Colgalt1
Glycosyltransferase 25 domain containing 1 (Predicted).
    
 
 0.420
Cd96
T-cell surface protein tactile; May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity).
   
  
 0.418
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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