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Itgb4 protein (Rattus norvegicus) - STRING interaction network
"Itgb4" - Integrin beta-4 in Rattus norvegicus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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Itgb4Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6-ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6-ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity) (1806 aa)    
Predicted Functional Partners:
Plec
Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics (4557 aa)
     
  0.995
Itga6
Integrin, alpha 6, isoform CRA_a; Integrin, alpha 6 (1090 aa)
     
  0.983
Dst
Dystonin (7358 aa)
     
  0.972
Itga7
Integrin alpha-7; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor for laminin- [...] (1135 aa)
     
  0.965
Lamb3
Laminin, beta 3, isoform CRA_a; Laminin, beta 3 (1172 aa)
     
 
  0.963
Itga3
Integrin, alpha 3 (1067 aa)
     
  0.961
Lama3
Laminin subunit alpha 3; Protein Lama3 (1725 aa)
     
  0.957
Col17a1
Collagen, type XVII, alpha 1 (1427 aa)
     
  0.955
Lamc2
Laminin, gamma 2 (1192 aa)
     
  0.953
Itga1
Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity) (1180 aa)
     
  0.947
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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