node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Itga2 | Itga3 | ENSRNOP00000072929 | ENSRNOP00000034608 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.882 |
Itga2 | Itga5 | ENSRNOP00000072929 | ENSRNOP00000071805 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.877 |
Itga2 | Itga6 | ENSRNOP00000072929 | ENSRNOP00000002075 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin, alpha 6, isoform CRA_a; Belongs to the integrin alpha chain family. | 0.903 |
Itga2 | Itga7 | ENSRNOP00000072929 | ENSRNOP00000028983 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin alpha-7 70 kDa form; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor [...] | 0.815 |
Itga2 | Itgb4 | ENSRNOP00000072929 | ENSRNOP00000073188 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | 0.939 |
Itga2 | Lamb3 | ENSRNOP00000072929 | ENSRNOP00000008440 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Laminin, beta 3, isoform CRA_a. | 0.839 |
Itga2 | Ptk2 | ENSRNOP00000072929 | ENSRNOP00000075518 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] | 0.934 |
Itga2 | Pxn | ENSRNOP00000072929 | ENSRNOP00000043928 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.932 |
Itga2 | Src | ENSRNOP00000072929 | ENSRNOP00000071837 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.778 |
Itga3 | Itga2 | ENSRNOP00000034608 | ENSRNOP00000072929 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.882 |
Itga3 | Itga5 | ENSRNOP00000034608 | ENSRNOP00000071805 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.954 |
Itga3 | Itga6 | ENSRNOP00000034608 | ENSRNOP00000002075 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin, alpha 6, isoform CRA_a; Belongs to the integrin alpha chain family. | 0.947 |
Itga3 | Itga7 | ENSRNOP00000034608 | ENSRNOP00000028983 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin alpha-7 70 kDa form; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor [...] | 0.908 |
Itga3 | Itgb4 | ENSRNOP00000034608 | ENSRNOP00000073188 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | 0.971 |
Itga3 | Lamb3 | ENSRNOP00000034608 | ENSRNOP00000008440 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Laminin, beta 3, isoform CRA_a. | 0.838 |
Itga3 | Ptk2 | ENSRNOP00000034608 | ENSRNOP00000075518 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] | 0.955 |
Itga3 | Pxn | ENSRNOP00000034608 | ENSRNOP00000043928 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.944 |
Itga3 | Src | ENSRNOP00000034608 | ENSRNOP00000071837 | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.755 |
Itga5 | Itga2 | ENSRNOP00000071805 | ENSRNOP00000072929 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.877 |
Itga5 | Itga3 | ENSRNOP00000071805 | ENSRNOP00000034608 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin alpha 3 variant B; Belongs to the integrin alpha chain family. | 0.954 |