| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Akr1a1 | Gk | ENSRNOP00000023072 | ENSRNOP00000074103 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D- glucuronic acid and D-glucurono-gamma-lactone. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are presen [...] | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | 0.909 |
| Akr1b1 | Akr1b7 | ENSRNOP00000012879 | ENSRNOP00000013423 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | 0.916 |
| Akr1b1 | Akr1b8 | ENSRNOP00000012879 | ENSRNOP00000065713 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | Aldo-keto reductase family 1, member B10 (Aldose reductase). | 0.917 |
| Akr1b1 | Gk | ENSRNOP00000012879 | ENSRNOP00000074103 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | 0.909 |
| Akr1b7 | Akr1b1 | ENSRNOP00000013423 | ENSRNOP00000012879 | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | 0.916 |
| Akr1b7 | Akr1b8 | ENSRNOP00000013423 | ENSRNOP00000065713 | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | Aldo-keto reductase family 1, member B10 (Aldose reductase). | 0.905 |
| Akr1b7 | Gk | ENSRNOP00000013423 | ENSRNOP00000074103 | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | 0.909 |
| Akr1b8 | Akr1b1 | ENSRNOP00000065713 | ENSRNOP00000012879 | Aldo-keto reductase family 1, member B10 (Aldose reductase). | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | 0.917 |
| Akr1b8 | Akr1b7 | ENSRNOP00000065713 | ENSRNOP00000013423 | Aldo-keto reductase family 1, member B10 (Aldose reductase). | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | 0.905 |
| Akr1b8 | Gk | ENSRNOP00000065713 | ENSRNOP00000074103 | Aldo-keto reductase family 1, member B10 (Aldose reductase). | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | 0.909 |
| Gk | Akr1a1 | ENSRNOP00000074103 | ENSRNOP00000023072 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D- glucuronic acid and D-glucurono-gamma-lactone. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are presen [...] | 0.909 |
| Gk | Akr1b1 | ENSRNOP00000074103 | ENSRNOP00000012879 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | 0.909 |
| Gk | Akr1b7 | ENSRNOP00000074103 | ENSRNOP00000013423 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. | 0.909 |
| Gk | Akr1b8 | ENSRNOP00000074103 | ENSRNOP00000065713 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Aldo-keto reductase family 1, member B10 (Aldose reductase). | 0.909 |
| Gk | Gpam | ENSRNOP00000074103 | ENSRNOP00000069320 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. | 0.930 |
| Gk | Gpat2 | ENSRNOP00000074103 | ENSRNOP00000018677 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Glycerol-3-phosphate acyltransferase 2, mitochondrial. | 0.913 |
| Gk | Gpat3 | ENSRNOP00000074103 | ENSRNOP00000002936 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Glycerol-3-phosphate acyltransferase 3; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (By similarity). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). | 0.945 |
| Gk | Gpat4 | ENSRNOP00000074103 | ENSRNOP00000024392 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta). | 0.919 |
| Gk | Gpd2 | ENSRNOP00000074103 | ENSRNOP00000043749 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Glycerol-3-phosphate dehydrogenase, mitochondrial. | 0.925 |
| Gk | Vdac3 | ENSRNOP00000074103 | ENSRNOP00000026197 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP; Belongs to the FGGY kinase family. | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. | 0.908 |
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