node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hmga1 | Hmga2 | ENSRNOP00000000580 | ENSRNOP00000061041 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family. | Non-histone chromosomal architectural protein HMGI-C. | 0.845 |
Hmga1 | Tp53 | ENSRNOP00000000580 | ENSRNOP00000074031 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.759 |
Hmga2 | Hmga1 | ENSRNOP00000061041 | ENSRNOP00000000580 | Non-histone chromosomal architectural protein HMGI-C. | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family. | 0.845 |
Hmga2 | Igf2bp2 | ENSRNOP00000061041 | ENSRNOP00000037578 | Non-histone chromosomal architectural protein HMGI-C. | Similar to IGF-II mRNA-binding protein 2 (Predicted). | 0.945 |
Hmga2 | Lin28b | ENSRNOP00000061041 | ENSRNOP00000037788 | Non-histone chromosomal architectural protein HMGI-C. | Lin-28 homolog B. | 0.704 |
Hmga2 | Smad1 | ENSRNOP00000061041 | ENSRNOP00000025079 | Non-histone chromosomal architectural protein HMGI-C. | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). Has been shown to be also activated by TGF- beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression (By similarity). | 0.744 |
Hmga2 | Smad2 | ENSRNOP00000061041 | ENSRNOP00000075341 | Non-histone chromosomal architectural protein HMGI-C. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.817 |
Hmga2 | Smad3 | ENSRNOP00000061041 | ENSRNOP00000037346 | Non-histone chromosomal architectural protein HMGI-C. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.846 |
Hmga2 | Smad4 | ENSRNOP00000061041 | ENSRNOP00000074882 | Non-histone chromosomal architectural protein HMGI-C. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.833 |
Hmga2 | Smad7 | ENSRNOP00000061041 | ENSRNOP00000024831 | Non-histone chromosomal architectural protein HMGI-C. | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...] | 0.702 |
Hmga2 | Snw1 | ENSRNOP00000061041 | ENSRNOP00000054619 | Non-histone chromosomal architectural protein HMGI-C. | Similar to Nuclear protein SkiP (Ski-interacting protein) (Predicted). | 0.754 |
Hmga2 | Tp53 | ENSRNOP00000061041 | ENSRNOP00000074031 | Non-histone chromosomal architectural protein HMGI-C. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.749 |
Igf2bp2 | Hmga2 | ENSRNOP00000037578 | ENSRNOP00000061041 | Similar to IGF-II mRNA-binding protein 2 (Predicted). | Non-histone chromosomal architectural protein HMGI-C. | 0.945 |
Igf2bp2 | Lin28b | ENSRNOP00000037578 | ENSRNOP00000037788 | Similar to IGF-II mRNA-binding protein 2 (Predicted). | Lin-28 homolog B. | 0.522 |
Lin28b | Hmga2 | ENSRNOP00000037788 | ENSRNOP00000061041 | Lin-28 homolog B. | Non-histone chromosomal architectural protein HMGI-C. | 0.704 |
Lin28b | Igf2bp2 | ENSRNOP00000037788 | ENSRNOP00000037578 | Lin-28 homolog B. | Similar to IGF-II mRNA-binding protein 2 (Predicted). | 0.522 |
Lin28b | Tp53 | ENSRNOP00000037788 | ENSRNOP00000074031 | Lin-28 homolog B. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.469 |
Smad1 | Hmga2 | ENSRNOP00000025079 | ENSRNOP00000061041 | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). Has been shown to be also activated by TGF- beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression (By similarity). | Non-histone chromosomal architectural protein HMGI-C. | 0.744 |
Smad1 | Smad2 | ENSRNOP00000025079 | ENSRNOP00000075341 | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). Has been shown to be also activated by TGF- beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression (By similarity). | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.976 |
Smad1 | Smad3 | ENSRNOP00000025079 | ENSRNOP00000037346 | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). Has been shown to be also activated by TGF- beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression (By similarity). | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.962 |