node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ino80e | Kctd13 | ENSRNOP00000027034 | ENSRNOP00000027129 | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | Potassium channel tetramerization domain-containing 13. | 0.563 |
Ino80e | Sez6l2 | ENSRNOP00000027034 | ENSRNOP00000035589 | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | Seizure-related 6 homolog-like 2. | 0.567 |
Ino80e | Taok2 | ENSRNOP00000027034 | ENSRNOP00000071896 | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.635 |
Kctd13 | Ino80e | ENSRNOP00000027129 | ENSRNOP00000027034 | Potassium channel tetramerization domain-containing 13. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.563 |
Kctd13 | Sez6l2 | ENSRNOP00000027129 | ENSRNOP00000035589 | Potassium channel tetramerization domain-containing 13. | Seizure-related 6 homolog-like 2. | 0.677 |
Kctd13 | Taok2 | ENSRNOP00000027129 | ENSRNOP00000071896 | Potassium channel tetramerization domain-containing 13. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.754 |
Map2k3 | Map2k6 | ENSRNOP00000008679 | ENSRNOP00000006217 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | 0.953 |
Map2k3 | Taok1 | ENSRNOP00000008679 | ENSRNOP00000021368 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | 0.931 |
Map2k3 | Taok2 | ENSRNOP00000008679 | ENSRNOP00000071896 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.946 |
Map2k3 | Taok3 | ENSRNOP00000008679 | ENSRNOP00000074994 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). | 0.920 |
Map2k6 | Map2k3 | ENSRNOP00000006217 | ENSRNOP00000008679 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | 0.953 |
Map2k6 | Taok1 | ENSRNOP00000006217 | ENSRNOP00000021368 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | 0.922 |
Map2k6 | Taok2 | ENSRNOP00000006217 | ENSRNOP00000071896 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.931 |
Map2k6 | Taok3 | ENSRNOP00000006217 | ENSRNOP00000074994 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). | 0.920 |
Pcdh8 | Taok2 | ENSRNOP00000017599 | ENSRNOP00000071896 | Protocadherin-8; Calcium-dependent cell-adhesion protein. May play a role in activity-induced synaptic reorganization underlying long term memory. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.687 |
Schip1 | Taok1 | ENSRNOP00000054283 | ENSRNOP00000021368 | Schwannomin-interacting protein 1. | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | 0.719 |
Schip1 | Taok2 | ENSRNOP00000054283 | ENSRNOP00000071896 | Schwannomin-interacting protein 1. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.618 |
Sema3a | Taok2 | ENSRNOP00000036472 | ENSRNOP00000071896 | Semaphorin-3A; May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.628 |
Sez6l2 | Ino80e | ENSRNOP00000035589 | ENSRNOP00000027034 | Seizure-related 6 homolog-like 2. | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | 0.567 |
Sez6l2 | Kctd13 | ENSRNOP00000035589 | ENSRNOP00000027129 | Seizure-related 6 homolog-like 2. | Potassium channel tetramerization domain-containing 13. | 0.677 |