node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Best1 | Lrrc8a | ENSRNOP00000007320 | ENSRNOP00000031726 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | 0.763 |
Best1 | Lrrc8b | ENSRNOP00000007320 | ENSRNOP00000002897 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Leucine-rich repeat-containing 8 VRAC subunit B. | 0.575 |
Best1 | Lrrc8c | ENSRNOP00000007320 | ENSRNOP00000002896 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8 [...] | 0.561 |
Best1 | Lrrc8d | ENSRNOP00000007320 | ENSRNOP00000002888 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or L [...] | 0.577 |
Best1 | Lrrc8e | ENSRNOP00000007320 | ENSRNOP00000037487 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel chara [...] | 0.581 |
Best1 | Ttyh1 | ENSRNOP00000007320 | ENSRNOP00000062088 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion; Belongs to the tweety family. | 0.488 |
Fcar | Ttyh1 | ENSRNOP00000069202 | ENSRNOP00000062088 | Fc fragment of IgA receptor. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion; Belongs to the tweety family. | 0.504 |
Gpr89b | Ttyh1 | ENSRNOP00000000106 | ENSRNOP00000062088 | G protein-coupled receptor 89B. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion; Belongs to the tweety family. | 0.543 |
Kcp | Lrrc8a | ENSRNOP00000043530 | ENSRNOP00000031726 | Kielin cysteine-rich BMP regulator. | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | 0.621 |
Kcp | Lrrc8b | ENSRNOP00000043530 | ENSRNOP00000002897 | Kielin cysteine-rich BMP regulator. | Leucine-rich repeat-containing 8 VRAC subunit B. | 0.458 |
Kcp | Lrrc8c | ENSRNOP00000043530 | ENSRNOP00000002896 | Kielin cysteine-rich BMP regulator. | Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8 [...] | 0.581 |
Kcp | Lrrc8d | ENSRNOP00000043530 | ENSRNOP00000002888 | Kielin cysteine-rich BMP regulator. | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or L [...] | 0.580 |
Kcp | Lrrc8e | ENSRNOP00000043530 | ENSRNOP00000037487 | Kielin cysteine-rich BMP regulator. | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel chara [...] | 0.587 |
Kcp | Ttyh1 | ENSRNOP00000043530 | ENSRNOP00000062088 | Kielin cysteine-rich BMP regulator. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion; Belongs to the tweety family. | 0.517 |
Lrrc8a | Best1 | ENSRNOP00000031726 | ENSRNOP00000007320 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. | 0.763 |
Lrrc8a | Kcp | ENSRNOP00000031726 | ENSRNOP00000043530 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Kielin cysteine-rich BMP regulator. | 0.621 |
Lrrc8a | Lrrc8b | ENSRNOP00000031726 | ENSRNOP00000002897 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Leucine-rich repeat-containing 8 VRAC subunit B. | 0.965 |
Lrrc8a | Lrrc8c | ENSRNOP00000031726 | ENSRNOP00000002896 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8 [...] | 0.997 |
Lrrc8a | Lrrc8d | ENSRNOP00000031726 | ENSRNOP00000002888 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or L [...] | 0.942 |
Lrrc8a | Lrrc8e | ENSRNOP00000031726 | ENSRNOP00000037487 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D [...] | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel chara [...] | 0.975 |