| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bglap | Itgb1 | ENSRNOP00000026530 | ENSRNOP00000014785 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.539 |
| Bglap | Spp1 | ENSRNOP00000026530 | ENSRNOP00000062358 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.931 |
| Itga4 | Itga5 | ENSRNOP00000006880 | ENSRNOP00000071805 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | 0.920 |
| Itga4 | Itga8 | ENSRNOP00000006880 | ENSRNOP00000022713 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.947 |
| Itga4 | Itga9 | ENSRNOP00000006880 | ENSRNOP00000015113 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.740 |
| Itga4 | Itgav | ENSRNOP00000006880 | ENSRNOP00000069681 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.965 |
| Itga4 | Itgb1 | ENSRNOP00000006880 | ENSRNOP00000014785 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.999 |
| Itga4 | Itgb3 | ENSRNOP00000006880 | ENSRNOP00000067271 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.988 |
| Itga4 | Itgb7 | ENSRNOP00000006880 | ENSRNOP00000016642 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.999 |
| Itga4 | Ptk2 | ENSRNOP00000006880 | ENSRNOP00000075518 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] | 0.946 |
| Itga4 | Spp1 | ENSRNOP00000006880 | ENSRNOP00000062358 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.939 |
| Itga5 | Itga4 | ENSRNOP00000071805 | ENSRNOP00000006880 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.920 |
| Itga5 | Itga9 | ENSRNOP00000071805 | ENSRNOP00000015113 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.790 |
| Itga5 | Itgav | ENSRNOP00000071805 | ENSRNOP00000069681 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.504 |
| Itga5 | Itgb1 | ENSRNOP00000071805 | ENSRNOP00000014785 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.999 |
| Itga5 | Itgb3 | ENSRNOP00000071805 | ENSRNOP00000067271 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] | 0.996 |
| Itga5 | Itgb7 | ENSRNOP00000071805 | ENSRNOP00000016642 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.923 |
| Itga5 | Ptk2 | ENSRNOP00000071805 | ENSRNOP00000075518 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] | 0.980 |
| Itga5 | Spp1 | ENSRNOP00000071805 | ENSRNOP00000062358 | Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.969 |
| Itga8 | Itga4 | ENSRNOP00000022713 | ENSRNOP00000006880 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.947 |
