node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc78 | Ccno | ENSRNOP00000020363 | ENSRNOP00000013871 | Coiled-coil domain-containing 78. | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | 0.451 |
Ccdc78 | Deup1 | ENSRNOP00000020363 | ENSRNOP00000069511 | Coiled-coil domain-containing 78. | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | 0.825 |
Ccdc78 | Mcidas | ENSRNOP00000020363 | ENSRNOP00000067993 | Coiled-coil domain-containing 78. | Multicilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. | 0.662 |
Ccno | Ccdc78 | ENSRNOP00000013871 | ENSRNOP00000020363 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Coiled-coil domain-containing 78. | 0.451 |
Ccno | Deup1 | ENSRNOP00000013871 | ENSRNOP00000069511 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | 0.738 |
Ccno | E2f4 | ENSRNOP00000013871 | ENSRNOP00000021145 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | E2F transcription factor 4. | 0.554 |
Ccno | Gmnc | ENSRNOP00000013871 | ENSRNOP00000055495 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Geminin coiled-coil domain-containing. | 0.587 |
Ccno | LOC103689994 | ENSRNOP00000013871 | ENSRNOP00000059088 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Radial spoke head protein 4 homolog A. | 0.605 |
Ccno | Mcidas | ENSRNOP00000013871 | ENSRNOP00000067993 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Multicilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. | 0.827 |
Ccno | Rfx2 | ENSRNOP00000013871 | ENSRNOP00000074363 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0- 3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T. Belongs to the RFX family. | 0.675 |
Ccno | Rfx3 | ENSRNOP00000013871 | ENSRNOP00000070787 | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | Regulatory factor X3. | 0.470 |
Deup1 | Ccdc78 | ENSRNOP00000069511 | ENSRNOP00000020363 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | Coiled-coil domain-containing 78. | 0.825 |
Deup1 | Ccno | ENSRNOP00000069511 | ENSRNOP00000013871 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | 0.738 |
Deup1 | E2f4 | ENSRNOP00000069511 | ENSRNOP00000021145 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | E2F transcription factor 4. | 0.513 |
Deup1 | Mcidas | ENSRNOP00000069511 | ENSRNOP00000067993 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | Multicilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. | 0.679 |
Deup1 | Rfx2 | ENSRNOP00000069511 | ENSRNOP00000074363 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0- 3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T. Belongs to the RFX family. | 0.530 |
E2f4 | Ccno | ENSRNOP00000021145 | ENSRNOP00000013871 | E2F transcription factor 4. | Similar to uracil-DNA glycosylase 2 (Predicted), isoform CRA_a; Belongs to the cyclin family. | 0.554 |
E2f4 | Deup1 | ENSRNOP00000021145 | ENSRNOP00000069511 | E2F transcription factor 4. | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). | 0.513 |
E2f4 | E2f5 | ENSRNOP00000021145 | ENSRNOP00000044464 | E2F transcription factor 4. | Transcription factor E2F5; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. | 0.978 |
E2f4 | Gmnc | ENSRNOP00000021145 | ENSRNOP00000055495 | E2F transcription factor 4. | Geminin coiled-coil domain-containing. | 0.683 |