Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IghmImmunoglobulin heavy constant mu. (495 aa)    
Predicted Functional Partners:
Jchain
Immunoglobulin joining chain.
   
  
 0.736
Igll1
Immunoglobulin lambda-like polypeptide 1.
   
 0.729
M0R7F5_RAT
IGv domain-containing protein.
   
 0.702
Lyn
Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-c [...]
   
 0.673
D3ZMS7_RAT
Ig-like domain-containing protein.
   
  0.605
M0RA79_RAT
Ig-like domain-containing protein.
   
 
  0.604
Cd5l
Cd5 molecule-like.
   
 0.603
D4ADL1_RAT
Ig-like domain-containing protein.
   
  0.596
LOC690813
Ig-like domain-containing protein.
   
  0.585
LOC100361706
Ig lambda-1 chain C region.
   
 
  0.580
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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