| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Appl1 | Appl2 | ENSRNOP00000018413 | ENSRNOP00000010986 | Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1. | DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interactio [...] | 0.983 |
| Appl1 | Ocrl | ENSRNOP00000018413 | ENSRNOP00000072408 | Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1. | Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] | 0.891 |
| Appl1 | Rab31 | ENSRNOP00000018413 | ENSRNOP00000063486 | Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.851 |
| Appl1 | Rbsn | ENSRNOP00000018413 | ENSRNOP00000015602 | Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.674 |
| Appl2 | Appl1 | ENSRNOP00000010986 | ENSRNOP00000018413 | DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interactio [...] | Adaptor protein, phosphotyrosine-interacting with PH domain and leucine zipper 1. | 0.983 |
| Appl2 | Rab31 | ENSRNOP00000010986 | ENSRNOP00000063486 | DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interactio [...] | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.814 |
| Gapvd1 | Gdi1 | ENSRNOP00000063504 | ENSRNOP00000070171 | GTPase-activating protein and VPS9 domains 1. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.502 |
| Gapvd1 | Gdi2 | ENSRNOP00000063504 | ENSRNOP00000024952 | GTPase-activating protein and VPS9 domains 1. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.504 |
| Gapvd1 | Rab31 | ENSRNOP00000063504 | ENSRNOP00000063486 | GTPase-activating protein and VPS9 domains 1. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.811 |
| Gapvd1 | Rabgef1 | ENSRNOP00000063504 | ENSRNOP00000001196 | GTPase-activating protein and VPS9 domains 1. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.758 |
| Gapvd1 | Rbsn | ENSRNOP00000063504 | ENSRNOP00000015602 | GTPase-activating protein and VPS9 domains 1. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.438 |
| Gapvd1 | Rin3 | ENSRNOP00000063504 | ENSRNOP00000071441 | GTPase-activating protein and VPS9 domains 1. | Ras and Rab interactor 3. | 0.622 |
| Gdi1 | Gapvd1 | ENSRNOP00000070171 | ENSRNOP00000063504 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | GTPase-activating protein and VPS9 domains 1. | 0.502 |
| Gdi1 | Gdi2 | ENSRNOP00000070171 | ENSRNOP00000024952 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.521 |
| Gdi1 | Rab31 | ENSRNOP00000070171 | ENSRNOP00000063486 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.707 |
| Gdi1 | Rabgef1 | ENSRNOP00000070171 | ENSRNOP00000001196 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.582 |
| Gdi1 | Rin3 | ENSRNOP00000070171 | ENSRNOP00000071441 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | Ras and Rab interactor 3. | 0.421 |
| Gdi2 | Gapvd1 | ENSRNOP00000024952 | ENSRNOP00000063504 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | GTPase-activating protein and VPS9 domains 1. | 0.504 |
| Gdi2 | Gdi1 | ENSRNOP00000024952 | ENSRNOP00000070171 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.521 |
| Gdi2 | Rab31 | ENSRNOP00000024952 | ENSRNOP00000063486 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.707 |
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