STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chaf1aChromatin assembly factor 1 subunit A. (907 aa)    
Predicted Functional Partners:
Chaf1b
Chromatin assembly factor 1, subunit B (P60), isoform CRA_a.
   
 0.991
Rbbp4
RB-binding protein 4, chromatin-remodeling factor.
   
 0.965
RGD1563620
Similar to retinoblastoma-binding protein 4.
   
 
 0.858
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae) (Predicted).
   
 
 0.855
Cbx5
Chromobox homolog 5 (Drosophila HP1a) (Predicted), isoform CRA_a.
   
 
 0.849
Mcm5
DNA helicase; Belongs to the MCM family.
   
  
 0.844
Mcm3
DNA helicase; Belongs to the MCM family.
   
  
 0.835
Mcm2
DNA helicase; Belongs to the MCM family.
   
 
 0.822
Mcm4
DNA helicase; Belongs to the MCM family.
   
 
 0.802
Pola1
DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA p [...]
   
 
 0.784
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.