Nr2e3 protein (Rattus norvegicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Amelx	Nr2e3	ENSRNOP00000048382	ENSRNOP00000064395	Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.	Nuclear receptor subfamily 2, group E, member 3.	0.732
Cnga1	Crx	ENSRNOP00000006469	ENSRNOP00000018858	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Cone-rod homeobox protein.	0.567
Cnga1	Gnat2	ENSRNOP00000006469	ENSRNOP00000026237	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b.	0.596
Cnga1	Nr2e3	ENSRNOP00000006469	ENSRNOP00000064395	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Nuclear receptor subfamily 2, group E, member 3.	0.751
Cnga1	Nrl	ENSRNOP00000006469	ENSRNOP00000024991	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Neural retina leucine zipper gene (Predicted).	0.633
Cnga1	Rcvrn	ENSRNOP00000006469	ENSRNOP00000004880	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Recoverin.	0.705
Cnga1	Rho	ENSRNOP00000006469	ENSRNOP00000061473	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.768
Cnga1	Rlbp1	ENSRNOP00000006469	ENSRNOP00000022962	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	Retinaldehyde binding protein 1 (Predicted), isoform CRA_a.	0.528
Crx	Cnga1	ENSRNOP00000018858	ENSRNOP00000006469	Cone-rod homeobox protein.	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	0.567
Crx	Gnat2	ENSRNOP00000018858	ENSRNOP00000026237	Cone-rod homeobox protein.	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b.	0.699
Crx	LOC100911492	ENSRNOP00000018858	ENSRNOP00000073390	Cone-rod homeobox protein.	Orthodenticle homeobox 2.	0.452
Crx	Nr2e3	ENSRNOP00000018858	ENSRNOP00000064395	Cone-rod homeobox protein.	Nuclear receptor subfamily 2, group E, member 3.	0.859
Crx	Nrl	ENSRNOP00000018858	ENSRNOP00000024991	Cone-rod homeobox protein.	Neural retina leucine zipper gene (Predicted).	0.826
Crx	Otx2	ENSRNOP00000018858	ENSRNOP00000064262	Cone-rod homeobox protein.	Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'; Belongs to the paired homeobox family. Bicoid subfamily.	0.523
Crx	Rcvrn	ENSRNOP00000018858	ENSRNOP00000004880	Cone-rod homeobox protein.	Recoverin.	0.849
Crx	Rho	ENSRNOP00000018858	ENSRNOP00000061473	Cone-rod homeobox protein.	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).	0.845
Crx	Rlbp1	ENSRNOP00000018858	ENSRNOP00000022962	Cone-rod homeobox protein.	Retinaldehyde binding protein 1 (Predicted), isoform CRA_a.	0.520
Gnat2	Cnga1	ENSRNOP00000026237	ENSRNOP00000006469	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b.	cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.	0.596
Gnat2	Crx	ENSRNOP00000026237	ENSRNOP00000018858	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b.	Cone-rod homeobox protein.	0.699
Gnat2	LOC100911492	ENSRNOP00000026237	ENSRNOP00000073390	Guanine nucleotide binding protein, alpha transducing 2 (Predicted), isoform CRA_b.	Orthodenticle homeobox 2.	0.492

page 1 of 5

Server load: low (14%) [HD]

Share

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About