Pnpla6 protein (Rattus norvegicus) - STRING interaction network

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Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gpcpd1	Pla2g15	ENSRNOP00000074931	ENSRNOP00000026996	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	0.885
Gpcpd1	Pla2g4a	ENSRNOP00000074931	ENSRNOP00000075329	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.	0.455
Gpcpd1	Pla2g4b	ENSRNOP00000074931	ENSRNOP00000061004	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Phospholipase A2.	0.428
Gpcpd1	Pla2g4d	ENSRNOP00000074931	ENSRNOP00000053100	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Phospholipase A2.	0.430
Gpcpd1	Pla2g4e	ENSRNOP00000074931	ENSRNOP00000031380	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Phospholipase A2.	0.429
Gpcpd1	Pla2g4f	ENSRNOP00000074931	ENSRNOP00000010959	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Phospholipase A2.	0.430
Gpcpd1	Plb1	ENSRNOP00000074931	ENSRNOP00000057888	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.	0.904
Gpcpd1	Pnpla6	ENSRNOP00000074931	ENSRNOP00000065231	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	Patatin-like phospholipase domain-containing 6.	0.910
Lpcat4	Pla2g15	ENSRNOP00000006776	ENSRNOP00000026996	Lysophosphatidylcholine acyltransferase 4.	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	0.915
Lpcat4	Pla2g4a	ENSRNOP00000006776	ENSRNOP00000075329	Lysophosphatidylcholine acyltransferase 4.	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.	0.905
Lpcat4	Pla2g4b	ENSRNOP00000006776	ENSRNOP00000061004	Lysophosphatidylcholine acyltransferase 4.	Phospholipase A2.	0.886
Lpcat4	Pla2g4d	ENSRNOP00000006776	ENSRNOP00000053100	Lysophosphatidylcholine acyltransferase 4.	Phospholipase A2.	0.886
Lpcat4	Pla2g4e	ENSRNOP00000006776	ENSRNOP00000031380	Lysophosphatidylcholine acyltransferase 4.	Phospholipase A2.	0.899
Lpcat4	Pla2g4f	ENSRNOP00000006776	ENSRNOP00000010959	Lysophosphatidylcholine acyltransferase 4.	Phospholipase A2.	0.887
Lpcat4	Pla2g6	ENSRNOP00000006776	ENSRNOP00000072104	Lysophosphatidylcholine acyltransferase 4.	85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose- stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2- induced chemotaxis through regulation of F-actin polymerization at the pseudopods (By [...]	0.903
Lpcat4	Plb1	ENSRNOP00000006776	ENSRNOP00000057888	Lysophosphatidylcholine acyltransferase 4.	Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.	0.891
Lpcat4	Pnpla6	ENSRNOP00000006776	ENSRNOP00000065231	Lysophosphatidylcholine acyltransferase 4.	Patatin-like phospholipase domain-containing 6.	0.904
Pla2g15	Gpcpd1	ENSRNOP00000026996	ENSRNOP00000074931	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity.	0.885
Pla2g15	Lpcat4	ENSRNOP00000026996	ENSRNOP00000006776	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	Lysophosphatidylcholine acyltransferase 4.	0.915
Pla2g15	Pla2g4a	ENSRNOP00000026996	ENSRNOP00000075329	Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.	0.949

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