Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Oit3Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development. (545 aa)    
Predicted Functional Partners:
Stab2
175 kDa stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity o [...]
   
  
 0.718
Clec4f
C-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.
   
 0.620
Clec1b
Similar to C-type lectin-like receptor 2 (Predicted), isoform CRA_a.
    
 0.617
Clec4g
C-type lectin domain family 4, member G.
    
 0.569
Cpn2
Carboxypeptidase N subunit 2.
   
 0.543
Vwa1
Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly.
    
 0.515
Map6d1
MAP6 domain-containing 1.
    
 0.508
Pgbd5
PiggyBac transposable element derived 5 (Predicted).
    
 
 0.493
Pla2g12b
Phospholipase A2, group XIIB.
   
 0.487
Katna1
Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]
    
 0.479
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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