| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Acp2 | Acp5 | ENSRNOP00000018620 | ENSRNOP00000074001 | Lysosomal acid phosphatase. | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | 0.951 |
| Acp2 | Blvrb | ENSRNOP00000018620 | ENSRNOP00000035090 | Lysosomal acid phosphatase. | Biliverdin reductase B (Flavin reductase (NADPH)) (Predicted), isoform CRA_b. | 0.911 |
| Acp2 | Enpp1 | ENSRNOP00000018620 | ENSRNOP00000019519 | Lysosomal acid phosphatase. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate [...] | 0.918 |
| Acp2 | Enpp3 | ENSRNOP00000018620 | ENSRNOP00000018695 | Lysosomal acid phosphatase. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.922 |
| Acp2 | Flad1 | ENSRNOP00000018620 | ENSRNOP00000028030 | Lysosomal acid phosphatase. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.900 |
| Acp2 | Rfk | ENSRNOP00000018620 | ENSRNOP00000030927 | Lysosomal acid phosphatase. | Riboflavin kinase. | 0.901 |
| Acp5 | Acp2 | ENSRNOP00000074001 | ENSRNOP00000018620 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Lysosomal acid phosphatase. | 0.951 |
| Acp5 | Blvrb | ENSRNOP00000074001 | ENSRNOP00000035090 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Biliverdin reductase B (Flavin reductase (NADPH)) (Predicted), isoform CRA_b. | 0.913 |
| Acp5 | Ctsk | ENSRNOP00000074001 | ENSRNOP00000028730 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | 0.803 |
| Acp5 | Enpp1 | ENSRNOP00000074001 | ENSRNOP00000019519 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate [...] | 0.918 |
| Acp5 | Enpp3 | ENSRNOP00000074001 | ENSRNOP00000018695 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.906 |
| Acp5 | Flad1 | ENSRNOP00000074001 | ENSRNOP00000028030 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.901 |
| Acp5 | LOC103689974 | ENSRNOP00000074001 | ENSRNOP00000013210 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in o [...] | 0.762 |
| Acp5 | Nfatc1 | ENSRNOP00000074001 | ENSRNOP00000055183 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Nuclear factor of-activated T-cells 1. | 0.808 |
| Acp5 | Rfk | ENSRNOP00000074001 | ENSRNOP00000030927 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | Riboflavin kinase. | 0.919 |
| Acp5 | Tnfsf11 | ENSRNOP00000074001 | ENSRNOP00000044212 | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | TNF superfamily member 11. | 0.748 |
| Blvrb | Acp2 | ENSRNOP00000035090 | ENSRNOP00000018620 | Biliverdin reductase B (Flavin reductase (NADPH)) (Predicted), isoform CRA_b. | Lysosomal acid phosphatase. | 0.911 |
| Blvrb | Acp5 | ENSRNOP00000035090 | ENSRNOP00000074001 | Biliverdin reductase B (Flavin reductase (NADPH)) (Predicted), isoform CRA_b. | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | 0.913 |
| Blvrb | Rfk | ENSRNOP00000035090 | ENSRNOP00000030927 | Biliverdin reductase B (Flavin reductase (NADPH)) (Predicted), isoform CRA_b. | Riboflavin kinase. | 0.915 |
| Ctsk | Acp5 | ENSRNOP00000028730 | ENSRNOP00000074001 | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates. | 0.803 |
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