node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl2 | Tbcb | ENSRNOP00000028525 | ENSRNOP00000066828 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-folding cofactor B. | 0.473 |
Arl2 | Tbcc | ENSRNOP00000028525 | ENSRNOP00000065504 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-specific chaperone c (Predicted). | 0.539 |
Arl2 | Tbcd | ENSRNOP00000028525 | ENSRNOP00000051796 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin folding cofactor D. | 0.943 |
Arl2 | Tbce | ENSRNOP00000028525 | ENSRNOP00000071747 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. | 0.669 |
Gan | Nedd8 | ENSRNOP00000016963 | ENSRNOP00000061284 | Giant axonal neuropathy (Predicted). | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.577 |
Gan | Tbcb | ENSRNOP00000016963 | ENSRNOP00000066828 | Giant axonal neuropathy (Predicted). | Tubulin-folding cofactor B. | 0.723 |
Nedd8 | Gan | ENSRNOP00000061284 | ENSRNOP00000016963 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Giant axonal neuropathy (Predicted). | 0.577 |
Nedd8 | Tbcb | ENSRNOP00000061284 | ENSRNOP00000066828 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Tubulin-folding cofactor B. | 0.501 |
Tbcb | Arl2 | ENSRNOP00000066828 | ENSRNOP00000028525 | Tubulin-folding cofactor B. | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.473 |
Tbcb | Gan | ENSRNOP00000066828 | ENSRNOP00000016963 | Tubulin-folding cofactor B. | Giant axonal neuropathy (Predicted). | 0.723 |
Tbcb | Nedd8 | ENSRNOP00000066828 | ENSRNOP00000061284 | Tubulin-folding cofactor B. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.501 |
Tbcb | Tbcc | ENSRNOP00000066828 | ENSRNOP00000065504 | Tubulin-folding cofactor B. | Tubulin-specific chaperone c (Predicted). | 0.718 |
Tbcb | Tbcd | ENSRNOP00000066828 | ENSRNOP00000051796 | Tubulin-folding cofactor B. | Tubulin folding cofactor D. | 0.844 |
Tbcb | Tbce | ENSRNOP00000066828 | ENSRNOP00000071747 | Tubulin-folding cofactor B. | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. | 0.906 |
Tbcb | Trappc4 | ENSRNOP00000066828 | ENSRNOP00000016145 | Tubulin-folding cofactor B. | Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. | 0.722 |
Tbcb | Tubb2a | ENSRNOP00000066828 | ENSRNOP00000071729 | Tubulin-folding cofactor B. | Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. | 0.542 |
Tbcb | Tubb2b | ENSRNOP00000066828 | ENSRNOP00000023582 | Tubulin-folding cofactor B. | Tubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity); Belongs to the tubulin family. | 0.541 |
Tbcb | Tubb4a | ENSRNOP00000066828 | ENSRNOP00000065633 | Tubulin-folding cofactor B. | Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | 0.472 |
Tbcc | Arl2 | ENSRNOP00000065504 | ENSRNOP00000028525 | Tubulin-specific chaperone c (Predicted). | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.539 |
Tbcc | Tbcb | ENSRNOP00000065504 | ENSRNOP00000066828 | Tubulin-specific chaperone c (Predicted). | Tubulin-folding cofactor B. | 0.718 |