node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Depdc5 | Flcn | ENSRNOP00000073874 | ENSRNOP00000004412 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | 0.504 |
Depdc5 | Mtor | ENSRNOP00000073874 | ENSRNOP00000014167 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.758 |
Depdc5 | Nprl2 | ENSRNOP00000073874 | ENSRNOP00000046410 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Tumor suppressor candidate 4, isoform CRA_a. | 0.999 |
Depdc5 | Nprl3 | ENSRNOP00000073874 | ENSRNOP00000071482 | DEP domain-containing 5, GATOR1 subcomplex subunit. | NPR3-like, GATOR1 complex subunit. | 0.999 |
Depdc5 | Rptor | ENSRNOP00000073874 | ENSRNOP00000005337 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Regulatory-associated protein of MTOR, complex 1. | 0.627 |
Depdc5 | RragB-2 | ENSRNOP00000073874 | ENSRNOP00000066990 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP binding B. | 0.896 |
Depdc5 | Rragc | ENSRNOP00000073874 | ENSRNOP00000023514 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP-binding C. | 0.989 |
Depdc5 | Rragd | ENSRNOP00000073874 | ENSRNOP00000061453 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.926 |
Depdc5 | Slc38a9 | ENSRNOP00000073874 | ENSRNOP00000013218 | DEP domain-containing 5, GATOR1 subcomplex subunit. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.485 |
Depdc5 | Wdr24 | ENSRNOP00000073874 | ENSRNOP00000026697 | DEP domain-containing 5, GATOR1 subcomplex subunit. | WD repeat domain 24. | 0.999 |
Flcn | Depdc5 | ENSRNOP00000004412 | ENSRNOP00000073874 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | DEP domain-containing 5, GATOR1 subcomplex subunit. | 0.504 |
Flcn | Mtor | ENSRNOP00000004412 | ENSRNOP00000014167 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.621 |
Flcn | Nprl2 | ENSRNOP00000004412 | ENSRNOP00000046410 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Tumor suppressor candidate 4, isoform CRA_a. | 0.752 |
Flcn | Nprl3 | ENSRNOP00000004412 | ENSRNOP00000071482 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | NPR3-like, GATOR1 complex subunit. | 0.719 |
Flcn | Rptor | ENSRNOP00000004412 | ENSRNOP00000005337 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Regulatory-associated protein of MTOR, complex 1. | 0.410 |
Flcn | RragB-2 | ENSRNOP00000004412 | ENSRNOP00000066990 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP binding B. | 0.894 |
Flcn | Rragc | ENSRNOP00000004412 | ENSRNOP00000023514 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP-binding C. | 0.994 |
Flcn | Rragd | ENSRNOP00000004412 | ENSRNOP00000061453 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Ras-related GTP binding D (Predicted), isoform CRA_b. | 0.987 |
Flcn | Slc38a9 | ENSRNOP00000004412 | ENSRNOP00000013218 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.886 |
Flcn | Wdr24 | ENSRNOP00000004412 | ENSRNOP00000026697 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). Belongs to the folliculin family. | WD repeat domain 24. | 0.732 |