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ENSRNOG00000050535 protein (Rattus norvegicus) - STRING interaction network
"ENSRNOG00000050535" - Ras-related GTP-binding protein B in Rattus norvegicus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSRNOG00000050535Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycle between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway; Belongs to the GTR/RAG GTP-binding protein family (374 aa)    
Predicted Functional Partners:
Nprl2
Tumor suppressor candidate 4, isoform CRA_a; Nitrogen permease regulator-like 2 (S. cerevisiae) (380 aa)
     
  0.982
Depdc5
DEP domain containing 5 (1456 aa)
     
  0.978
Rragc
Ras-related GTP binding C (398 aa)
     
0.973
Nprl3
Alpha globin regulatory element containing protein; Nitrogen permease regulator-like 3 (S. cerevisiae) (469 aa)
     
  0.971
Rraga
Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death; Bel [...] (313 aa)
       
0.970
Wdr24
WD repeat domain 24 (790 aa)
     
 
  0.967
Rragd
Ras-related GTP binding D (399 aa)
     
0.964
Rptor
Regulatory associated protein of MTOR, complex 1 (1335 aa)
     
  0.957
Lamtor2
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (125 aa)
     
  0.956
Lamtor5
Hepatitis B virus x interacting protein (Predicted), isoform CRA_a; Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 (156 aa)
     
  0.949
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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