Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Hist2h4a-5Histone cluster 2, H4. (103 aa)    
Predicted Functional Partners:
LOC684762-2
Histone H3.2-like.
   
 0.810
LOC684762-3
Histone H4-like.
   
 0.810
LOC684762-4
Histone H4-like.
   
 0.804
LOC684762-5
Similar to CG31613-PA.
   
 0.793
Hist2h3c2
Histone H4-like.
   
 0.784
LOC684762-6
Histone H4-like.
   
 0.784
LOC684762-7
Histone H4-like.
   
 0.784
Hist3h2ba
Histone H2B; Belongs to the histone H2B family.
   
 
 0.727
H2ac20
Histone H2A; Belongs to the histone H2A family.
   
 
 0.711
H1f4
Histone H1.4; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
   
 
 0.709
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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