node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdyl | Mier3 | ENSRNOP00000048651 | ENSRNOP00000069147 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | MIER family member 3. | 0.483 |
Ctbs | Mier3 | ENSRNOP00000020972 | ENSRNOP00000069147 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. | MIER family member 3. | 0.608 |
Ctbs | Pde12 | ENSRNOP00000020972 | ENSRNOP00000074876 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | 0.635 |
Dnttip1 | Mier3 | ENSRNOP00000020280 | ENSRNOP00000069147 | Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. | MIER family member 3. | 0.486 |
Dytn | Mier3 | ENSRNOP00000059439 | ENSRNOP00000069147 | Dystrotelin. | MIER family member 3. | 0.731 |
Dytn | Ptdss2 | ENSRNOP00000059439 | ENSRNOP00000021925 | Dystrotelin. | Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity); Belongs to the phosphatidyl serine synthase family. | 0.622 |
Mier3 | Cdyl | ENSRNOP00000069147 | ENSRNOP00000048651 | MIER family member 3. | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 0.483 |
Mier3 | Ctbs | ENSRNOP00000069147 | ENSRNOP00000020972 | MIER family member 3. | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. | 0.608 |
Mier3 | Dnttip1 | ENSRNOP00000069147 | ENSRNOP00000020280 | MIER family member 3. | Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. | 0.486 |
Mier3 | Dytn | ENSRNOP00000069147 | ENSRNOP00000059439 | MIER family member 3. | Dystrotelin. | 0.731 |
Mier3 | Mocs2 | ENSRNOP00000069147 | ENSRNOP00000073722 | MIER family member 3. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | 0.571 |
Mier3 | Mrps30 | ENSRNOP00000069147 | ENSRNOP00000016190 | MIER family member 3. | Mitochondrial ribosomal protein S30 (Predicted), isoform CRA_a. | 0.535 |
Mier3 | Pde12 | ENSRNOP00000069147 | ENSRNOP00000074876 | MIER family member 3. | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | 0.507 |
Mier3 | Prmt2 | ENSRNOP00000069147 | ENSRNOP00000039976 | MIER family member 3. | HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae), isoform CRA_c; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. | 0.571 |
Mier3 | Ptdss2 | ENSRNOP00000069147 | ENSRNOP00000021925 | MIER family member 3. | Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity); Belongs to the phosphatidyl serine synthase family. | 0.492 |
Mier3 | RGD1308706 | ENSRNOP00000069147 | ENSRNOP00000023169 | MIER family member 3. | Similar to RIKEN cDNA 4921524J17 (Predicted), isoform CRA_b. | 0.520 |
Mocs2 | Mier3 | ENSRNOP00000073722 | ENSRNOP00000069147 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | MIER family member 3. | 0.571 |
Mocs2 | Mrps30 | ENSRNOP00000073722 | ENSRNOP00000016190 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | Mitochondrial ribosomal protein S30 (Predicted), isoform CRA_a. | 0.485 |
Mrps30 | Mier3 | ENSRNOP00000016190 | ENSRNOP00000069147 | Mitochondrial ribosomal protein S30 (Predicted), isoform CRA_a. | MIER family member 3. | 0.535 |
Mrps30 | Mocs2 | ENSRNOP00000016190 | ENSRNOP00000073722 | Mitochondrial ribosomal protein S30 (Predicted), isoform CRA_a. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. | 0.485 |