| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Afg3l2 | Clpp | ENSRNOP00000024632 | ENSRNOP00000066481 | AFG3-like matrix AAA peptidase subunit 2. | ATP-dependent Clp protease proteolytic subunit. | 0.787 |
| Afg3l2 | Clpx | ENSRNOP00000024632 | ENSRNOP00000050010 | AFG3-like matrix AAA peptidase subunit 2. | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in h [...] | 0.842 |
| Afg3l2 | Lonp1 | ENSRNOP00000024632 | ENSRNOP00000066618 | AFG3-like matrix AAA peptidase subunit 2. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] | 0.793 |
| Afg3l2 | Maip1 | ENSRNOP00000024632 | ENSRNOP00000021533 | AFG3-like matrix AAA peptidase subunit 2. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.561 |
| Afg3l2 | Oma1 | ENSRNOP00000024632 | ENSRNOP00000009515 | AFG3-like matrix AAA peptidase subunit 2. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] | 0.774 |
| Afg3l2 | Parl | ENSRNOP00000024632 | ENSRNOP00000029124 | AFG3-like matrix AAA peptidase subunit 2. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.640 |
| Afg3l2 | Phb | ENSRNOP00000024632 | ENSRNOP00000066502 | AFG3-like matrix AAA peptidase subunit 2. | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. | 0.832 |
| Afg3l2 | Phb2 | ENSRNOP00000024632 | ENSRNOP00000017472 | AFG3-like matrix AAA peptidase subunit 2. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) [...] | 0.885 |
| Afg3l2 | Pmpca | ENSRNOP00000024632 | ENSRNOP00000037642 | AFG3-like matrix AAA peptidase subunit 2. | Mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. | 0.809 |
| Afg3l2 | Spg7 | ENSRNOP00000024632 | ENSRNOP00000073276 | AFG3-like matrix AAA peptidase subunit 2. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.924 |
| Clpp | Afg3l2 | ENSRNOP00000066481 | ENSRNOP00000024632 | ATP-dependent Clp protease proteolytic subunit. | AFG3-like matrix AAA peptidase subunit 2. | 0.787 |
| Clpp | Clpx | ENSRNOP00000066481 | ENSRNOP00000050010 | ATP-dependent Clp protease proteolytic subunit. | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in h [...] | 0.999 |
| Clpp | Lonp1 | ENSRNOP00000066481 | ENSRNOP00000066618 | ATP-dependent Clp protease proteolytic subunit. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] | 0.927 |
| Clpp | Oma1 | ENSRNOP00000066481 | ENSRNOP00000009515 | ATP-dependent Clp protease proteolytic subunit. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] | 0.700 |
| Clpp | Parl | ENSRNOP00000066481 | ENSRNOP00000029124 | ATP-dependent Clp protease proteolytic subunit. | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). | 0.639 |
| Clpp | Phb2 | ENSRNOP00000066481 | ENSRNOP00000017472 | ATP-dependent Clp protease proteolytic subunit. | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) [...] | 0.514 |
| Clpp | Pmpca | ENSRNOP00000066481 | ENSRNOP00000037642 | ATP-dependent Clp protease proteolytic subunit. | Mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. | 0.637 |
| Clpp | Spg7 | ENSRNOP00000066481 | ENSRNOP00000073276 | ATP-dependent Clp protease proteolytic subunit. | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function ; In the N-terminal section; belongs to the AAA ATPase family. | 0.767 |
| Clpx | Afg3l2 | ENSRNOP00000050010 | ENSRNOP00000024632 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in h [...] | AFG3-like matrix AAA peptidase subunit 2. | 0.842 |
| Clpx | Clpp | ENSRNOP00000050010 | ENSRNOP00000066481 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in h [...] | ATP-dependent Clp protease proteolytic subunit. | 0.999 |
