Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PigrPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. (782 aa)    
Predicted Functional Partners:
Jchain
Immunoglobulin joining chain.
  
 0.998
Tspan8
Tetraspanin.
   
   0.974
Piga
Phosphatidylinositol glycan anchor biosynthesis, class A.
   
 
 0.857
Mis12
Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
    
   0.824
Fcar
Fc fragment of IgA receptor.
   
 
 0.818
Fcamr
Fc fragment of IgA and IgM receptor.
   
0.813
Cd79a
Ig-like domain-containing protein.
   
 
 0.811
IGHG1_RAT
Ig gamma-1 chain C region.
    
 0.795
Cd79b
B29/Ig-beta/CD79b.
   
 
 0.782
LOC100361706
Ig lambda-1 chain C region.
   
 
 0.760
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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