STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ddx3xDEAD-box helicase 3, X-linked; Belongs to the DEAD box helicase family. (662 aa)    
Predicted Functional Partners:
Ddx3y
DEAD-box helicase 3, Y-linked; Belongs to the DEAD box helicase family.
  
  
0.938
Tbk1
Similar to TANK-binding kinase 1.
   
 0.933
Nlrp3
NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...]
     
 0.872
Eif2s3
Eukaryotic translation initiation factor 2 subunit 3, X-linked; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary com [...]
   
 
 0.829
Gsdmd
Gasdermin domain containing 1 (Predicted), isoform CRA_a.
   
 
 0.807
Kdm6a
Lysine demethylase 6A.
   
 
 0.794
Eftud2
Elongation factor Tu GTP-binding domain-containing 2.
   
 
 0.791
Kdm5d
Lysine demethylase 5D.
   
 
 0.779
Kdm5c
Lysine (K)-specific demethylase 5C.
   
 
 0.779
Dhx33
DEAH (Asp-Glu-Ala-His) box polypeptide 33 (Predicted).
   
 0.778
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.