STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSDMDGasdermin D. (481 aa)    
Predicted Functional Partners:
H0VET0_CAVPO
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.973
H0VK31_CAVPO
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.973
LOC100725217
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.965
CASP12
Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.
   
 0.952
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.896
IL1B
Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.
    
 0.883
CASP9
Caspase 9; Belongs to the peptidase C14A family.
    
 0.875
CASP10
Caspase 10; Belongs to the peptidase C14A family.
   
 0.875
NLRP3
NLR family pyrin domain containing 3.
  
  
 0.859
Casp7
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.852
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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