STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLA2G2APhospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferat [...] (145 aa)    
Predicted Functional Partners:
PLA2G4A
Phospholipase A2.
     
 0.827
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
     
 0.745
ENSCPOP00000029546
UBIQUITIN_CONJUGAT_2 domain-containing protein.
     
 0.745
ENSCPOP00000030838
UBIQUITIN_CONJUGAT_2 domain-containing protein.
     
 0.745
CYP2E1
Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.
     
 0.704
PLA2G3
Phospholipase A2 group III.
     
 0.703
ALOX5
Arachidonate 5-lipoxygenase.
   
 
 0.692
ENPP6
Ectonucleotide pyrophosphatase/phosphodiesterase 6.
     
 0.689
PTDSS2
Phosphatidylserine synthase 2.
     
 0.689
PLA2G1B
Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family.
  
 
 
0.687
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.