STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPH1Tryptophan hydroxylase 1. (420 aa)    
Predicted Functional Partners:
PCBD1
Pterin-4 alpha-carbinolamine dehydratase 1.
  
 0.981
PCBD2
Pterin-4 alpha-carbinolamine dehydratase 2.
  
 0.981
QDPR
Quinoid dihydropteridine reductase.
 
 
 0.949
TDO2
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
  
 
 0.937
SPR
Sepiapterin reductase.
  
 
 0.935
IDO2
Indoleamine 2,3-dioxygenase 2.
   
 
 0.933
TH
Tyrosine hydroxylase.
  
 
0.919
DDC
Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family.
   
 0.916
AKR1B1
Aldo-keto reductase family 1 member B.
   
 
 0.914
Dhfr
DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.
     
 0.913
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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