STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD46Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (387 aa)    
Predicted Functional Partners:
C3
Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation.
    
 0.901
LOC100728345
Anaphylatoxin-like domain-containing protein.
    
 0.893
H0W7A0_CAVPO
NTR domain-containing protein.
    
 0.887
MSN
Moesin.
    
 0.887
Cfi
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.867
RDX
Radixin.
    
 0.737
EZR
Ezrin.
    
 0.737
C5
Complement C5.
    
 0.711
Cfb
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.704
NF2
Neurofibromin 2.
    
 0.682
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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