STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SH2B3SH2B adaptor protein 3. (557 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.974
GRB2
Growth factor receptor bound protein 2.
    
0.949
NTRK1
Tyrosine-protein kinase receptor.
    
 0.931
NTRK3
Tyrosine-protein kinase receptor.
    
 0.927
NTRK2
Tyrosine-protein kinase receptor.
    
 0.926
SH2B1
SH2B adaptor protein 1.
    
0.920
JAK3
Tyrosine-protein kinase.
    
 0.881
TYK2
Tyrosine-protein kinase.
    
 0.784
JAK1
Tyrosine-protein kinase.
    
 0.784
CBL
Cbl proto-oncogene.
    
 0.754
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.