Cxcr2 protein (Cavia porcellus) - STRING interaction network

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Score

Cxcr2

Interleukin-8 receptor CXCR2; Belongs to the G-protein coupled receptor 1 family. (352 aa)

Predicted Functional Partners:

CXCL1

0.994

Cxcr1

0.957

CXCL12

0.946

GNA12

0.941

CXCL6

0.938

CCL5

0.937

CXCL10

0.937

GNAQ

0.934

LOC100732436

0.932

CXCL9

0.927

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL5	CXCL1	ENSCPOP00000007949	ENSCPOP00000029891	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	0.974
CCL5	CXCL10	ENSCPOP00000007949	ENSCPOP00000023256	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine ligand 10.	0.999
CCL5	CXCL12	ENSCPOP00000007949	ENSCPOP00000022617	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.998
CCL5	CXCL6	ENSCPOP00000007949	ENSCPOP00000014633	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine.	0.825
CCL5	CXCL9	ENSCPOP00000007949	ENSCPOP00000022028	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine.	0.998
CCL5	Cxcr1	ENSCPOP00000007949	ENSCPOP00000018298	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.932
CCL5	Cxcr2	ENSCPOP00000007949	ENSCPOP00000001276	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Interleukin-8 receptor CXCR2; Belongs to the G-protein coupled receptor 1 family.	0.937
CXCL1	CCL5	ENSCPOP00000029891	ENSCPOP00000007949	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.974
CXCL1	CXCL10	ENSCPOP00000029891	ENSCPOP00000023256	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine ligand 10.	0.955
CXCL1	CXCL12	ENSCPOP00000029891	ENSCPOP00000022617	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.969
CXCL1	CXCL6	ENSCPOP00000029891	ENSCPOP00000014633	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine.	0.980
CXCL1	CXCL9	ENSCPOP00000029891	ENSCPOP00000022028	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine.	0.960
CXCL1	Cxcr1	ENSCPOP00000029891	ENSCPOP00000018298	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.986
CXCL1	Cxcr2	ENSCPOP00000029891	ENSCPOP00000001276	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	Interleukin-8 receptor CXCR2; Belongs to the G-protein coupled receptor 1 family.	0.994
CXCL10	CCL5	ENSCPOP00000023256	ENSCPOP00000007949	C-X-C motif chemokine ligand 10.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.999
CXCL10	CXCL1	ENSCPOP00000023256	ENSCPOP00000029891	C-X-C motif chemokine ligand 10.	Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family.	0.955
CXCL10	CXCL12	ENSCPOP00000023256	ENSCPOP00000022617	C-X-C motif chemokine ligand 10.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.997
CXCL10	CXCL6	ENSCPOP00000023256	ENSCPOP00000014633	C-X-C motif chemokine ligand 10.	C-X-C motif chemokine.	0.869
CXCL10	CXCL9	ENSCPOP00000023256	ENSCPOP00000022028	C-X-C motif chemokine ligand 10.	C-X-C motif chemokine.	0.999
CXCL10	Cxcr1	ENSCPOP00000023256	ENSCPOP00000018298	C-X-C motif chemokine ligand 10.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.930