node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA1D | CALM2 | ENSCPOP00000032217 | ENSCPOP00000001454 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Calmodulin isoform 3; Belongs to the calmodulin family. | 0.937 |
CACNA1D | CAMK2A | ENSCPOP00000032217 | ENSCPOP00000005978 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | 0.932 |
CACNA1D | NOS2 | ENSCPOP00000032217 | ENSCPOP00000016760 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] | 0.431 |
CACNA1D | NOS3 | ENSCPOP00000032217 | ENSCPOP00000003945 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. | 0.431 |
CACNA1D | PPP3CA | ENSCPOP00000032217 | ENSCPOP00000008833 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Serine/threonine-protein phosphatase. | 0.921 |
CACNA1D | PPP3CB | ENSCPOP00000032217 | ENSCPOP00000007213 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Serine/threonine-protein phosphatase. | 0.921 |
CACNA1D | PPP3CC | ENSCPOP00000032217 | ENSCPOP00000001008 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Serine/threonine-protein phosphatase. | 0.921 |
CACNA1D | RYR1 | ENSCPOP00000032217 | ENSCPOP00000014131 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Ryanodine receptor 1. | 0.616 |
CACNA1D | RYR2 | ENSCPOP00000032217 | ENSCPOP00000027721 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Ryanodine receptor 2. | 0.796 |
CALM2 | CACNA1D | ENSCPOP00000001454 | ENSCPOP00000032217 | Calmodulin isoform 3; Belongs to the calmodulin family. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.937 |
CALM2 | CAMK2A | ENSCPOP00000001454 | ENSCPOP00000005978 | Calmodulin isoform 3; Belongs to the calmodulin family. | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | 0.951 |
CALM2 | CAMKK2 | ENSCPOP00000001454 | ENSCPOP00000031580 | Calmodulin isoform 3; Belongs to the calmodulin family. | Calcium/calmodulin dependent protein kinase kinase 2. | 0.925 |
CALM2 | NOS2 | ENSCPOP00000001454 | ENSCPOP00000016760 | Calmodulin isoform 3; Belongs to the calmodulin family. | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] | 0.927 |
CALM2 | NOS3 | ENSCPOP00000001454 | ENSCPOP00000003945 | Calmodulin isoform 3; Belongs to the calmodulin family. | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. | 0.927 |
CALM2 | PPP3CA | ENSCPOP00000001454 | ENSCPOP00000008833 | Calmodulin isoform 3; Belongs to the calmodulin family. | Serine/threonine-protein phosphatase. | 0.929 |
CALM2 | PPP3CB | ENSCPOP00000001454 | ENSCPOP00000007213 | Calmodulin isoform 3; Belongs to the calmodulin family. | Serine/threonine-protein phosphatase. | 0.942 |
CALM2 | PPP3CC | ENSCPOP00000001454 | ENSCPOP00000001008 | Calmodulin isoform 3; Belongs to the calmodulin family. | Serine/threonine-protein phosphatase. | 0.929 |
CALM2 | RYR1 | ENSCPOP00000001454 | ENSCPOP00000014131 | Calmodulin isoform 3; Belongs to the calmodulin family. | Ryanodine receptor 1. | 0.946 |
CALM2 | RYR2 | ENSCPOP00000001454 | ENSCPOP00000027721 | Calmodulin isoform 3; Belongs to the calmodulin family. | Ryanodine receptor 2. | 0.960 |
CAMK2A | CACNA1D | ENSCPOP00000005978 | ENSCPOP00000032217 | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.932 |