Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DTX4Deltex E3 ubiquitin ligase 4. (620 aa)    
Predicted Functional Partners:
NOTCH1
Notch receptor 1.
    
 0.998
NOTCH2
Notch receptor 2.
    
 0.982
Notch4
Uncharacterized protein.
    
 0.977
ITCH
E3 ubiquitin-protein ligase.
    
 0.948
DTX3L
Deltex E3 ubiquitin ligase 3L.
  
 
0.930
Dtx2
Uncharacterized protein.
  
  
 
0.922
NOTCH3
Notch receptor 3.
    
 0.881
WWP1
E3 ubiquitin-protein ligase.
    
 0.855
WWP2
E3 ubiquitin-protein ligase.
    
 0.855
NUDCD1
NudC domain containing 1.
    
   0.724
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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