Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PSAPSaposin-C; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. (536 aa)    
Predicted Functional Partners:
GLA
Alpha-galactosidase.
   
 0.993
GPR37
G protein-coupled receptor 37.
     
 0.990
GPR37L1
G protein-coupled receptor 37 like 1.
     
 0.981
GBA
Glucosylceramidase.
   
 0.979
GALC
Galactosylceramidase.
    
 
 0.950
SORT1
Sortilin.
    
 
 0.938
ARSA
Arylsulfatase A.
     
 0.936
NAGA
Alpha-galactosidase.
   
 0.927
Hexa
Beta-hexosaminidase.
   
 
 0.925
HEXB
Hexosaminidase subunit beta.
   
 
 0.919
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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