TTC9 protein (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

TTC9

Tetratricopeptide repeat domain 9. (186 aa)

Predicted Functional Partners:

PTGES3L

0.739

PTGES3

0.731

Hsp90aa1

0.729

HSP90AB1

0.729

TSC1

0.729

LOC100725824

0.729

TRAP1

0.729

HSP90B1

0.662

RYR1

0.626

RYR2

0.626

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSP90AB1	HSP90B1	ENSCPOP00000003507	ENSCPOP00000028008	Heat shock protein 90 alpha family class B member 1.	Heat shock protein 90 beta family member 1.	0.942
HSP90AB1	PTGES3	ENSCPOP00000003507	ENSCPOP00000029406	Heat shock protein 90 alpha family class B member 1.	Prostaglandin E synthase 3.	0.983
HSP90AB1	PTGES3L	ENSCPOP00000003507	ENSCPOP00000006122	Heat shock protein 90 alpha family class B member 1.	Prostaglandin E synthase 3 like.	0.919
HSP90AB1	TTC9	ENSCPOP00000003507	ENSCPOP00000001630	Heat shock protein 90 alpha family class B member 1.	Tetratricopeptide repeat domain 9.	0.729
HSP90B1	HSP90AB1	ENSCPOP00000028008	ENSCPOP00000003507	Heat shock protein 90 beta family member 1.	Heat shock protein 90 alpha family class B member 1.	0.942
HSP90B1	Hsp90aa1	ENSCPOP00000028008	ENSCPOP00000001822	Heat shock protein 90 beta family member 1.	Heat shock protein 90 alpha family class A member 1.	0.791
HSP90B1	LOC100725824	ENSCPOP00000028008	ENSCPOP00000022877	Heat shock protein 90 beta family member 1.	HATPase_c domain-containing protein.	0.787
HSP90B1	PTGES3	ENSCPOP00000028008	ENSCPOP00000029406	Heat shock protein 90 beta family member 1.	Prostaglandin E synthase 3.	0.908
HSP90B1	PTGES3L	ENSCPOP00000028008	ENSCPOP00000006122	Heat shock protein 90 beta family member 1.	Prostaglandin E synthase 3 like.	0.901
HSP90B1	TRAP1	ENSCPOP00000028008	ENSCPOP00000031857	Heat shock protein 90 beta family member 1.	TNF receptor associated protein 1.	0.736
HSP90B1	TSC1	ENSCPOP00000028008	ENSCPOP00000003988	Heat shock protein 90 beta family member 1.	TSC complex subunit 1.	0.702
HSP90B1	TTC9	ENSCPOP00000028008	ENSCPOP00000001630	Heat shock protein 90 beta family member 1.	Tetratricopeptide repeat domain 9.	0.662
Hsp90aa1	HSP90B1	ENSCPOP00000001822	ENSCPOP00000028008	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 90 beta family member 1.	0.791
Hsp90aa1	PTGES3	ENSCPOP00000001822	ENSCPOP00000029406	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3.	0.975
Hsp90aa1	PTGES3L	ENSCPOP00000001822	ENSCPOP00000006122	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3 like.	0.919
Hsp90aa1	TTC9	ENSCPOP00000001822	ENSCPOP00000001630	Heat shock protein 90 alpha family class A member 1.	Tetratricopeptide repeat domain 9.	0.729
LOC100725824	HSP90B1	ENSCPOP00000022877	ENSCPOP00000028008	HATPase_c domain-containing protein.	Heat shock protein 90 beta family member 1.	0.787
LOC100725824	PTGES3	ENSCPOP00000022877	ENSCPOP00000029406	HATPase_c domain-containing protein.	Prostaglandin E synthase 3.	0.975
LOC100725824	PTGES3L	ENSCPOP00000022877	ENSCPOP00000006122	HATPase_c domain-containing protein.	Prostaglandin E synthase 3 like.	0.919
LOC100725824	TTC9	ENSCPOP00000022877	ENSCPOP00000001630	HATPase_c domain-containing protein.	Tetratricopeptide repeat domain 9.	0.729

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.911

expected number of edges:

18

PPI enrichment p-value:

2.2e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042254

Ribosome biogenesis

9 of 392

1.59

2.92

5.41e-10

GO:0006391

Transcription initiation from mitochondrial promoter

3 of 3

3.23

2.78

9.17e-06

GO:0042274

Ribosomal small subunit biogenesis

5 of 95

1.95

2.42

7.10e-06

GO:0006364

rRNA processing

6 of 272

1.58

1.94

1.06e-05

GO:0030490

Maturation of SSU-rRNA

3 of 49

2.02

1.31

0.0029

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034246

Mitochondrial transcription factor activity

2 of 2

3.23

1.42

0.0028

GO:0001018

Mitochondrial promoter sequence-specific DNA binding

2 of 3

3.06

1.41

0.0028

GO:0030515

snoRNA binding

3 of 39

2.12

1.34

0.0028

GO:0003723

RNA binding

10 of 1780

0.98

1.08

1.98e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030684

Preribosome

4 of 75

1.96

1.86

0.00016

GO:0042645

Mitochondrial nucleoid

3 of 43

2.08

1.6

0.00079

GO:0034388

Pwp2p-containing subcomplex of 90S preribosome

2 of 5

2.84

1.54

0.0016

GO:0030688

Preribosome, small subunit precursor

2 of 13

2.42

1.25

0.0050

GO:0032040

Small-subunit processome

2 of 36

1.98

0.84

0.0261

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15888

Mixed, incl. Small-subunit processome, and Positive regulation of rRNA processing

7 of 70

2.23

4.96

1.91e-11

CL:15903

Small-subunit processome, and Positive regulation of rRNA processing

5 of 42

2.31

3.75

2.88e-08

CL:18639

Mixed, incl. Mitochondrial transcription initiation, and Helix-hairpin-helix motif

3 of 7

2.87

2.78

7.98e-06

CL:15907

Small-subunit processome, and Positive regulation of rRNA processing

3 of 27

2.28

1.92

0.00022

CL:16011

Mixed, incl. AARP2CN (NUC121) domain, and Regulation of ribosomal subunit export from nucleus

2 of 5

2.84

1.5

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

4 of 127

1.73

1.65

0.00025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163282

Mitochondrial transcription initiation

3 of 3

3.23

3.18

1.71e-06

MAP-75944

Transcription from mitochondrial promoters

3 of 4

3.11

3.16

1.79e-06

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

7 of 426

1.45

1.92

1.71e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

7 of 441

1.43

1.9

1.71e-06

MAP-72312

rRNA processing

7 of 452

1.42

1.88

1.71e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

7 of 82

2.16

4.77

2.72e-11

GOCC:0034388

Pwp2p-containing subcomplex of 90S preribosome

3 of 7

2.87

2.75

8.98e-06

GOCC:0030686

90S preribosome

4 of 40

2.23

2.66

5.70e-06

GOCC:0030688

Preribosome, small subunit precursor

3 of 27

2.28

1.9

0.00024

GOCC:1990904

Ribonucleoprotein complex

8 of 794

1.24

1.54

1.56e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04003

Dip2/Utp12 Family

2 of 3

3.06

1.19

0.0072

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