STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)    
Predicted Functional Partners:
PTGES
Prostaglandin E synthase.
     
 0.961
PTGIS
Prostaglandin I2 synthase; Belongs to the cytochrome P450 family.
    
 0.960
PTGS1
Prostaglandin-endoperoxide synthase 1.
  
0.950
PTGES2
Prostaglandin E synthase 2; Belongs to the GST superfamily.
     
 0.940
PLA2G4A
Phospholipase A2.
  
 
 0.939
PTGES3
Prostaglandin E synthase 3.
     
 0.935
HPGDS
Hematopoietic prostaglandin D synthase.
     
 0.929
ALOX5
Arachidonate 5-lipoxygenase.
     
 0.919
CYP2E1
Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.
     
 0.919
LOC100716044
Cytochrome P450 2C-like protein; Belongs to the cytochrome P450 family.
     
 0.913
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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