STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (536 aa)    
Predicted Functional Partners:
CD81
Tetraspanin.
    
 0.997
TSPAN32
Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family.
    
 0.975
CD79A
CD79a molecule.
   
 0.972
LYN
Tyrosine-protein kinase.
   
 0.969
VAV2
Vav guanine nucleotide exchange factor 2.
   
 0.957
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.949
CD79B
CD79b molecule.
   
 0.939
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
     
 0.917
FCRLA
Fc receptor like A.
   
 
 0.917
CR2
Complement C3d receptor 2.
   
 0.917
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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