USP8 protein (Cavia porcellus) - STRING interaction network

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USP8

Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa)

Predicted Functional Partners:

STAM2

0.997

EGFR

0.996

RNF41

0.995

STAM

0.987

HGS

0.979

UBB

0.969

BIRC6

0.954

GRAP2

0.950

Ubc

0.950

YWHAZ

0.943

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC6	GRAP2	ENSCPOP00000012037	ENSCPOP00000028785	Baculoviral IAP repeat containing 6.	GRB2 related adaptor protein 2.	0.427
BIRC6	RNF41	ENSCPOP00000012037	ENSCPOP00000022380	Baculoviral IAP repeat containing 6.	Ring finger protein 41.	0.992
BIRC6	UBB	ENSCPOP00000012037	ENSCPOP00000029946	Baculoviral IAP repeat containing 6.	Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.783
BIRC6	USP8	ENSCPOP00000012037	ENSCPOP00000002001	Baculoviral IAP repeat containing 6.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.954
BIRC6	Ubc	ENSCPOP00000012037	ENSCPOP00000031925	Baculoviral IAP repeat containing 6.	Uncharacterized protein.	0.783
EGFR	GRAP2	ENSCPOP00000000034	ENSCPOP00000028785	Receptor protein-tyrosine kinase.	GRB2 related adaptor protein 2.	0.977
EGFR	HGS	ENSCPOP00000000034	ENSCPOP00000019336	Receptor protein-tyrosine kinase.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.985
EGFR	RNF41	ENSCPOP00000000034	ENSCPOP00000022380	Receptor protein-tyrosine kinase.	Ring finger protein 41.	0.943
EGFR	STAM	ENSCPOP00000000034	ENSCPOP00000008315	Receptor protein-tyrosine kinase.	Signal transducing adaptor molecule.	0.699
EGFR	STAM2	ENSCPOP00000000034	ENSCPOP00000002589	Receptor protein-tyrosine kinase.	Signal transducing adaptor molecule 2.	0.956
EGFR	UBB	ENSCPOP00000000034	ENSCPOP00000029946	Receptor protein-tyrosine kinase.	Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.969
EGFR	USP8	ENSCPOP00000000034	ENSCPOP00000002001	Receptor protein-tyrosine kinase.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.996
EGFR	Ubc	ENSCPOP00000000034	ENSCPOP00000031925	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.933
EGFR	YWHAZ	ENSCPOP00000000034	ENSCPOP00000025259	Receptor protein-tyrosine kinase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family.	0.963
GRAP2	BIRC6	ENSCPOP00000028785	ENSCPOP00000012037	GRB2 related adaptor protein 2.	Baculoviral IAP repeat containing 6.	0.427
GRAP2	EGFR	ENSCPOP00000028785	ENSCPOP00000000034	GRB2 related adaptor protein 2.	Receptor protein-tyrosine kinase.	0.977
GRAP2	HGS	ENSCPOP00000028785	ENSCPOP00000019336	GRB2 related adaptor protein 2.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.427
GRAP2	STAM	ENSCPOP00000028785	ENSCPOP00000008315	GRB2 related adaptor protein 2.	Signal transducing adaptor molecule.	0.518
GRAP2	STAM2	ENSCPOP00000028785	ENSCPOP00000002589	GRB2 related adaptor protein 2.	Signal transducing adaptor molecule 2.	0.518
GRAP2	UBB	ENSCPOP00000028785	ENSCPOP00000029946	GRB2 related adaptor protein 2.	Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...]	0.464