TNF protein (Cavia porcellus) - STRING interaction network

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TNF

Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)

Predicted Functional Partners:

TNFRSF1B

0.999

TNFRSF1A

0.999

NFKB1

0.998

RELA

0.998

RIPK1

0.998

ADAM17

0.997

TNFAIP3

0.994

IKBKB

0.993

TRADD

0.993

CHUK

0.993

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	TNF	ENSCPOP00000010172	ENSCPOP00000002129	ADAM metallopeptidase domain 17.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.997
ADAM17	TNFRSF1A	ENSCPOP00000010172	ENSCPOP00000028998	ADAM metallopeptidase domain 17.	TNF receptor superfamily member 1A.	0.561
ADAM17	TNFRSF1B	ENSCPOP00000010172	ENSCPOP00000018355	ADAM metallopeptidase domain 17.	TNF receptor superfamily member 1B.	0.873
CHUK	IKBKB	ENSCPOP00000032009	ENSCPOP00000009478	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	NFKB1	ENSCPOP00000032009	ENSCPOP00000007014	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor kappa B subunit 1.	0.999
CHUK	RELA	ENSCPOP00000032009	ENSCPOP00000016204	Component of inhibitor of nuclear factor kappa B kinase complex.	RELA proto-oncogene, NF-kB subunit.	0.999
CHUK	RIPK1	ENSCPOP00000032009	ENSCPOP00000022121	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor interacting serine/threonine kinase 1.	0.998
CHUK	TNF	ENSCPOP00000032009	ENSCPOP00000002129	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.993
CHUK	TNFAIP3	ENSCPOP00000032009	ENSCPOP00000009670	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF alpha induced protein 3.	0.910
CHUK	TNFRSF1A	ENSCPOP00000032009	ENSCPOP00000028998	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor superfamily member 1A.	0.992
CHUK	TRADD	ENSCPOP00000032009	ENSCPOP00000009726	Component of inhibitor of nuclear factor kappa B kinase complex.	TNFRSF1A associated via death domain.	0.990
IKBKB	CHUK	ENSCPOP00000009478	ENSCPOP00000032009	Inhibitor of nuclear factor kappa B kinase subunit beta.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999
IKBKB	NFKB1	ENSCPOP00000009478	ENSCPOP00000007014	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nuclear factor kappa B subunit 1.	0.999
IKBKB	RELA	ENSCPOP00000009478	ENSCPOP00000016204	Inhibitor of nuclear factor kappa B kinase subunit beta.	RELA proto-oncogene, NF-kB subunit.	0.999
IKBKB	RIPK1	ENSCPOP00000009478	ENSCPOP00000022121	Inhibitor of nuclear factor kappa B kinase subunit beta.	Receptor interacting serine/threonine kinase 1.	0.998
IKBKB	TNF	ENSCPOP00000009478	ENSCPOP00000002129	Inhibitor of nuclear factor kappa B kinase subunit beta.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.993
IKBKB	TNFAIP3	ENSCPOP00000009478	ENSCPOP00000009670	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF alpha induced protein 3.	0.968
IKBKB	TNFRSF1A	ENSCPOP00000009478	ENSCPOP00000028998	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor superfamily member 1A.	0.999
IKBKB	TRADD	ENSCPOP00000009478	ENSCPOP00000009726	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNFRSF1A associated via death domain.	0.981
NFKB1	CHUK	ENSCPOP00000007014	ENSCPOP00000032009	Nuclear factor kappa B subunit 1.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.999

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