STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HORMAD2HORMA domain containing 2. (281 aa)    
Predicted Functional Partners:
SYCP3
Synaptonemal complex protein 3.
   
 
 0.890
DMC1
Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.
   
 
 0.805
TRIP13
Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.
   
 
 0.792
SPO11
SPO11 initiator of meiotic double stranded breaks.
   
  
 0.764
SYCP1
Synaptonemal complex protein 1.
   
 
 0.759
SYCE1
Synaptonemal complex central element protein 1.
      
 0.697
REC8
REC8 meiotic recombination protein.
   
 
 0.675
MSH4
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
   
  
 0.658
SMC3
Structural maintenance of chromosomes protein.
    
 
 0.650
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 
 0.617
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.