node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1S | C3 | ENSCPOP00000026834 | ENSCPOP00000018087 | Complement C1s; Belongs to the peptidase S1 family. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.905 |
C1S | C3AR1 | ENSCPOP00000026834 | ENSCPOP00000019559 | Complement C1s; Belongs to the peptidase S1 family. | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | 0.631 |
C1S | C5 | ENSCPOP00000026834 | ENSCPOP00000002041 | Complement C1s; Belongs to the peptidase S1 family. | Complement C5. | 0.518 |
C1S | CD46 | ENSCPOP00000026834 | ENSCPOP00000001183 | Complement C1s; Belongs to the peptidase S1 family. | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.575 |
C1S | CFP | ENSCPOP00000026834 | ENSCPOP00000006537 | Complement C1s; Belongs to the peptidase S1 family. | Properdin; A positive regulator of the alternate pathway of complement (By similarity). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity). | 0.737 |
C1S | CR2 | ENSCPOP00000026834 | ENSCPOP00000025900 | Complement C1s; Belongs to the peptidase S1 family. | Complement C3d receptor 2. | 0.613 |
C1S | Cfb | ENSCPOP00000026834 | ENSCPOP00000014382 | Complement C1s; Belongs to the peptidase S1 family. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.808 |
C1S | Masp2 | ENSCPOP00000026834 | ENSCPOP00000010454 | Complement C1s; Belongs to the peptidase S1 family. | CUB domain-containing protein. | 0.570 |
C3 | C1S | ENSCPOP00000018087 | ENSCPOP00000026834 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C1s; Belongs to the peptidase S1 family. | 0.905 |
C3 | C3AR1 | ENSCPOP00000018087 | ENSCPOP00000019559 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | 0.950 |
C3 | C5 | ENSCPOP00000018087 | ENSCPOP00000002041 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C5. | 0.935 |
C3 | CD46 | ENSCPOP00000018087 | ENSCPOP00000001183 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.901 |
C3 | CFP | ENSCPOP00000018087 | ENSCPOP00000006537 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Properdin; A positive regulator of the alternate pathway of complement (By similarity). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity). | 0.974 |
C3 | CR2 | ENSCPOP00000018087 | ENSCPOP00000025900 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement C3d receptor 2. | 0.918 |
C3 | Cfb | ENSCPOP00000018087 | ENSCPOP00000014382 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.966 |
C3 | Cfi | ENSCPOP00000018087 | ENSCPOP00000003800 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Uncharacterized protein; Belongs to the peptidase S1 family. | 0.971 |
C3 | ITGAM | ENSCPOP00000018087 | ENSCPOP00000026019 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] | 0.958 |
C3 | Masp2 | ENSCPOP00000018087 | ENSCPOP00000010454 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | CUB domain-containing protein. | 0.921 |
C3AR1 | C1S | ENSCPOP00000019559 | ENSCPOP00000026834 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement C1s; Belongs to the peptidase S1 family. | 0.631 |
C3AR1 | C3 | ENSCPOP00000019559 | ENSCPOP00000018087 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.950 |